PREPARATION OF ERLOTINIB HYDROCHLORIDE

Ta Van Dai, Le Tat Thanh, Pham Quoc Long, Tran Thi Thu Thuy

Abstract


Erlotinib hydrochloride (Tarceva) is a targeted cancer therapy drug approved for treatment of non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. An efficient and economical synthetic method of title compound from ethyl 3,4-dihydroxybenzoate is described in 6 steps with overall yield of 51 %.


Keywords


Erlotinib, non small cell lung cancer, synthesis.

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DOI: https://doi.org/10.15625/0866-708X/53/6/5239 Display counter: Abstract : 42 views. PDF : 260 views.

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Published by Vietnam Academy of Science and Technology