SYNTHESIS OF TWO NEW HYDROXIMINOSTEROIDS FROM CHOLESTEROL AND THEIR BIOLOGICAL EVALUATION

Authors

  • Thu Thuy Thi Tran Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
  • Ha Thi Dinh Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
  • Baskar Salvaraja Natural Product Research Center, Korean Institute of Science and Technology, Gangneung
  • Long Quoc Pham Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
  • Quang Dai Ngo Vietnam National Chemical Group
  • Nghi Huu Do Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
  • Jae Wook Lee Natural Product Research Center, Korean Institute of Science and Technology, Gangneung

DOI:

https://doi.org/10.15625/2525-2518/57/5/13809

Keywords:

cholesterol, hydroximinosteroid, HeLa, HepG2, T98G

Abstract

A simple and efficient synthesis of two new hydroximinosteroidal derivatives (11, 13) from cholesterol was described. The cytotoxicity of these compounds, their intermediates were evaluated on human cancer cell lines including Hep-G2, HeLa and T98G. Compound 13 presented a potent antiproliferative effect to T98G cancer cell at 2.9 mM of IC50. In addition, the antimicrobial assay showed that two new oximes 11 and 13 were active against E. coli and S. aureus strain (MIC :50 mg/mL).

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Author Biography

Thu Thuy Thi Tran, Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology

Bioorganic Chemistry Laboratory, Deputy Ditector

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Published

2019-10-08

Issue

Section

Natural Products