Cytotoxic xanthonoids from the stem bark of Garcinia hanburyi collected in Vietnam

Nguyen Thi Kim An; Ngo Dai Quang; Pham Quoc Long; Tran Thi Thu Thuy

doi:10.15625/2525-2518/58/2/14367

Author affiliations

Authors

Nguyen Thi Kim An Hanoi University of Industry, 289 Cau Dien Street, North Tu Liem district, Ha Noi, Viet Nam
Ngo Dai Quang Vietnam National Chemical Group -1A Trang Tien, Hoan Kiem, Ha Noi, Viet Nam
Pham Quoc Long Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Tran Thi Thu Thuy Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/58/2/14367

Keywords:

prenylated caged xanthones, Garcinia hanburyi, gambogic acid, cytotoxicity, LLC and SK-LU-1

Abstract

Five prenylated caged xanthones, desoxymorellin, morellic acid, gambogic acid, isogambogic acid and 10α-butoxy gambogic acid , were isolated from the stem bark of Garcinia hanburyi collected in Vietnam. Their structures were elucidated by detailed 1D, 2D NMR spectroscopic analyses and comparison with reported data. Two major constituents, gambogic acid and isogambogic acid, displayed strong cytotoxicity against LLC and SK-LU-1cell lines with IC₅₀ values in the range from 0.35±0.05 µM to 2.26±0.19 µM. This is the first study on the cytotoxicity of gambogic acid and isogambogic acid against LLC and SK-LU-1 lung cancer cell lines.

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