Some Characteristics And Allopurinol Release Of Carrageenan/ Allopurinol Films Using Polyethylene Oxide As A Dispersion Aid Agent


  • Chinh Thuy Nguyen Institute for Tropical Technology, VAST
  • Phuong Thi Nguyen Dai Nam University, 56 Vu Trong Phung, Thanh Xuan, Ha Noi
  • Manh Quoc Vu Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi
  • Hoang Thai Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18, Hoang Quoc Viet, Cau Giay, Ha Noi
  • Trung Quoc Vu Faculty of Chemistry, Hanoi National University of Education, No. 136 Xuan Thuy Road, Cau Giay, Ha Noi



Carrageenan, drug release, drug loading capacity, allopurinol, morphology.


This paper presents the effect of carrageenan (CG) on some characteristics and drug release of allopurinol in the presence of polyethylene oxide (PEO) as a dispersion aid agent. The samples were prepared in film shape by solution method, in which, the content of PEO was changed from 1 wt.% to 5 wt.% and the content of allopurinol was fixed at 10 wt.% in comparison with carrageenan weight. FTIR , FESEM, UV-Vis methods were used to evaluate characterizations and morphology of CG/PEO/allopurinol films.


Download data is not yet available.

Author Biography

Chinh Thuy Nguyen, Institute for Tropical Technology, VAST

Cán bộ nghiên cứu


Coviello, T., Matricardi, P., Marianecci, C., Alhaique, F. - Polysaccharide hydrogels for modified release formulations, J. Control. Rel. 119(1) (2007), 5–24.

Jiao, G., Yu, G., Zhang, J., Ewart, H.S. - Chemical structures and bioactivities of sulfated polysaccharides from marine algae, Marine Drugs 9(2) (2011), 196–223.

Bhardwaj, T. R., Kanwar, M., Lal, R., Gupta, A. - Natural gums and modified natural gums as sustained-release carriers, Drug Development and Industrial Pharmacy, 26 (2000), 1025–1038.

Campo, V. L., Kawano, D. F., Silva, D. B., Jr., Carvalho, D. I. - Carrageenans: Biological properties, chemical modifications and structural analysis-A review, Carbohydrate Polymers, 77 (2009), 167–180.

Handbook of Pharmaceutical Excipients, Pharmacy Practice, 10(2) (2012), 117.

Tobacman, J.K. - Review of harmful gastrointestinal effects of carrageenan in animal experiments, Environ. Health Perspect. 109(10) (2001), 983–994.

Nerurkar, J., Jun, H.W., Price, J.C., Park, M.O. - Controlled-release matrix tablets of ibuprofen using cellulose ethers and carrageenans: effect of formulation factors on dissolution rates, Eur. J. Pharm. Biopharm. 61(1–2) (2005), 56–68.

Baloglu, E., Senyigit, T. - A design and evaluation of layered matrix tablet formulations of

metoprolol tartrate, Aaps Pharmscitech 11(2) (2010), 563–573.

Tapia, C., Escobar, Z., Costa, E., Sapag-Hagar, J., Valenzuela, F., Basualto, C. - Comparative studies on polyelectrolyte complexes and mixtures of chitosan-alginate and chitosan-carrageenan as prolonged diltiazem clorhydrate release systems, Eur. J. Pharm. Biopharm. 57(1) (2004), 65–75.

Ghanam, D., Kleinebudde, P. - Suitability of kappa-carrageenan pellets for the formulation of multiparticulate tablets with modified release, Int. J. Pharm. 409(1–2) (2011), 9–18.

Varghese, J.S., Chellappa, N., Fathima, N.N. - Gelatin-carrageenan hydrogels: role of pore size distribution on drug delivery process, Colloids Surf B Biointerfaces 113 (2014), 346–351.

Dai, W. G., Dong, L.C., Song, Y. Q. - Nanosizing of a drug/carrageenan complex to increase solubility and dissolution rate, Int. J. Pharm. 342(1–2) (2007), 201–207.

Nantes, C.I., Pesarini, J.R., Mauro, M.O., Monreal, A.C.D., Ramires, A.D., Oliveira, R.J. - Evaluation of the antimutagenic activity and mode of action of carrageenan fiber in cultured meristematic cells of Allium cepa, Genet. Mol. Res. 13(4) (2014), 9523–9532.

Bosio, V.E., Cacicedo, M.L., Calvignac, B., Leon, I., Beuvier, T., Boury, F., Castro, G.R. - Synthesis and characterization of CaCO3-biopolymer hybrid nanoporous microparticles for controlled release of doxorubicin, Colloids Surf B-Biointerfaces 123 (2014), 158–169.

Cacicedo, M.L., Cesca, K., Bosio, V.E., Porto, L.M., Castro, G.R. - Self-assembly of carrageenin CaCO3 hybrid microparticles on bacterial cellulose films for doxorubicin sustained delivery, J. Appl. Biomed. 13(3) (2015), 239–248.

Ling, G., Zhang, T., Zhang, P., Sun, J., He, Z. - Nanostructured lipid-carrageenan hybrid

carriers (NLCCs) for controlled delivery of mitoxantrone hydrochloride to enhance anticancer activity bypassing the BCRP-mediated efflux, Drug Develop. Indust. Pharm. 42(8) (2016), 1351–1359.

Juntapram, K., Praphairaksit, N., Siraleartmukul, K., Muangsin, N. - Electrosprayed polyelectrolyte complexes between mucoadhesive N,N,N,-trimethylchitosan-homocysteine thiolactone and alginate/carrageenan for camptothecin delivery, Carbohyd. Polym. 90(4) (2012).

Raman, M., Devi, V., Doble, M. - Biocompatible ι-carrageenan-γ-maghemite nanocomposite for biomedical applications–synthesis, characterization and in vitro anticancer efficacy, J. Nanobiotechnol. 13(1) (2015), 1469–1479.

Chinh, N. T., Trang, N. T. T, Thanh, D. T. M., Hang, T. T. X, Giang, N. V., Hoang, T., Dung, N. T., Quan, P. M. - Thermal property, morphology and hydrolysis ability of poly(lactic acid)/chitosan nanocomposites using polyethylene oxide, Journal of Applied Polymer Science, 132(12) (2015), 3934-3939.

Chinh, N. T., Loc, T. T, Giang, L. D., Trang, N. T. T, Mai, T. T., Hoang, T. - Effect of polyethylene oxide on properties of chitosan/alginate/lovastatine composites, Vietnam Journal of Science and Technology, 56(2A) (2018), 156-162.

Trang, N. T. T, Chinh, N. T., Mai, T. T., Trung, T. H, Hoang, T. - Investigation of effect of polyethylene oxide on properties and morphology of polylactic acid/chitosan/quinine composites, Vietnam J. Chem., 57(1) (2019), 52-56.

Jagdale S. C., Musale V., Kuchekar B. S., Chabukswar A. R. - Physicochemical characterization and solubility enhancement studies of allopurinol solid dispersions, Brazilian Journal of Pharmaceutical Sciences, 47(3) (2011),