chemical constituents from methanolic extract of Garcinia mackeaniana leaves and their antioxidant activity

Ha Nguyen Thi Thu, Cuong Pham Van, Tra Nguyen Thanh, Anh Le Thi Tu, Cham Ba Thi, Son Ninh The

Abstract


A phytochemical investigation of the methanolic extract of Garcinia mackeaniana leaves led to the isolation, and determination of five secondary metabolites, including one benzophenone 4,3',4'-trihydroxy-2,6-dimethoxybenzophenone (1), two flavone C-glucosides vitexin (2) and its 2''-O-acetyl derivative (3), one biflavone amentoflavone (4), and one mono-phenol methyl protocatechuate (5). The chemical structures of these compounds were characterized by the NMR-spectroscopic method. These isolated compounds were isolated from G. mackeaniana species for the first time. Benzophenone derivative 1 has shown to be associated with a significant IC50 value of 14.97±0.8 µg/mL in the DPPH-antioxidant assay.


Keywords


Garcinia mackeaniana; leaves; phytochemistry; antioxidant activity

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DOI: https://doi.org/10.15625/2525-2518/58/4/14680 Display counter: Abstract : 51 views. PDF : 7 views.

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