Alkaloids and cyclopeptides from the marine-derived fungus Aspergillus sp. M512

Authors

  • Do Thi Quynh Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Cao Duc Tuan Faculty of Pharmacy, Haiphong University of Medicine and Pharmacy, Hai Phong, Viet Nam
  • Dang Van Chuc Faculty of Pharmacy, Haiphong University of Medicine and Pharmacy, Hai Phong, Viet Nam
  • Hoang Thi Hong Lien Department of Science and Technology, Haiphong University, Hai Phong, Viet Nam
  • Le Khanh Huyen Faculty of Pharmacy, Haiphong University of Medicine and Pharmacy, Hai Phong, Viet Nam
  • Le Thi Hong Minh Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Pham Van Cuong Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Nguyen Van Hung Faculty of Pharmacy, Haiphong University of Medicine and Pharmacy, Hai Phong, Viet Nam
  • Young Ho Kim College of Pharmacy, Chungnam National University, Korea
  • Doan Thi Mai Huong Institute of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/58/5/15022

Keywords:

Aspergillus, alkaloid, cyclodipeptide, antimicrobial activity

Abstract

In the course of our screening program, the EtOAc extract of an Aspergillus sp. (strain M512) exhibited antimicrobial activities against three Gram Positive bacteria, and one yeast strain. This paper reported the isolation and structural elucidation of seven secondary metabolites including two alkaloids (1-2) and five cyclodipeptides (3-7) from culture broth of Aspergillus sp. M517. All isolated compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Except compound 1 and 2, with MIC values ranged from 32 to 128 μg/mL, five other compounds do not show inhibition activities against tested microorganisms.

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Published

2020-10-16

How to Cite

[1]
D. T. . Quynh, “Alkaloids and cyclopeptides from the marine-derived fungus Aspergillus sp. M512”, Vietnam J. Sci. Technol., vol. 58, no. 5, pp. 541–548, Oct. 2020.

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Section

Natural Products