SECONDARY METABOLITES FROM MICROMONOSPORA SP. (G044)

Authors

  • Cao Duc Tuan Institute of Marine Biochemistry-VAST
  • Doan Thi Mai Huong Institute of Marine Biochemistry-VAST
  • Truong Bich Ngan Institute of Marine Biochemistry-VAST
  • Vu Thi Quyen Institute of Marine Biochemistry-VAST
  • Le Thi Hong Minh Institute of Marine Biochemistry-VAST
  • Murphy Brian University of Illinois at Chicago
  • Chau Van Minh Institute of Marine Biochemistry-VAST
  • Pham Van Cuong Institute of Marine Biochemistry-VAST

DOI:

https://doi.org/10.15625/2525-2518/55/3/8641

Keywords:

Micromonospora sp., marine microorganisms, antimicrobial activity, Cyclo-(Pro-Trp), Cyclo-(Pro-Met), Cyclo-(Pro-Val).

Abstract

In the course of our screening program, the EtOAc extract of a Micromonospora sp. (strain G044) from sponge Tethya aurantium of the sea of Côtô - Thanh Lân exhibited antimicrobial activity against Enterococcus faecalis, Bacillus cereus and Candida albicans. In this paper, we reported the isolation and structural elucidation of six secondary metabolites Cyclo-(Pro-Trp) (1), Cyclo-(Pro-Met) (2), Cyclo-(Pro-Val) (4), N-acetyltryptamine (3), uridine (5), and 2-phenylacetic acid (6) from the cultures broth of Micromonospora sp. (strain G044). The structures of 1 – 6 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compound 1 inhibited Escherichia coli with a MIC value of 128 µg/ml.

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Author Biography

Doan Thi Mai Huong, Institute of Marine Biochemistry-VAST

Department of Organic Synthesis

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Published

2017-06-12

Issue

Section

Natural Products