LIGNANS FROM LEAVES OF AMESIODENDRON CHINENSE AND THEIR CYTOTOXIC ACTIVITY

Authors

  • Ho Van Ban
  • Trinh Thi Thanh Van
  • Vu Van Chien
  • Nguyen Thi Hue
  • Pham Thi Hang
  • Nguyen Le Tuan
  • Nguyen Xuan Nhiem
  • Pham Van Cuong
  • Nguyen Quoc Vuong

DOI:

https://doi.org/10.15625/2525-2518/58/4/14877

Keywords:

Amesiodendron chinense, ( )-aptosimon, ( )-isolariciresinol, cleomiscosin A, cleomiscosin C, cytotoxicity.

Abstract

ABSTRACTFrom leaves of Amesiodendron chinense (Mer.) Hu four lignans (+)-aptosimon (1), (+)-isolariciresinol (2), (-)-cleomiscosin A (3), and (-)-cleomiscosin C (3) were isolated. Their structures were determined by spectroscopic analysis including MS, 1D and 2D NMR as well as by comparison with reported data in literature. All compounds were evaluated for cytotoxic activities against five human cancer cell lines, KB, SK-LU-1, MCF-7, HepG-2, and SW-480. They showed weak cytotoxic activity on five tested human cancer cell lines with IC50 values ranging from 32.61 to 95.18 µg/ml.

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Author Biographies

Ho Van Ban

2Graduate University of Science and Technology, VAST3 Natural Science department, Quy Nhon University; 170 An Duong Vuong, Quy Nhon

Trinh Thi Thanh Van

1Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)2Graduate University of Science and Technology, VAST

Vu Van Chien

1Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)2Graduate University of Science and Technology, VAST

Nguyen Thi Hue

1Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)2Graduate University of Science and Technology, VAST

Pham Thi Hang

1Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)2Graduate University of Science and Technology, VAST

Nguyen Le Tuan

 3 Natural Science department, Quy Nhon University; 170 An Duong Vuong, Quy Nhon

Nguyen Xuan Nhiem

1Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)2Graduate University of Science and Technology, VAST

Pham Van Cuong

1Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)2Graduate University of Science and Technology, VAST

Nguyen Quoc Vuong

1Institue of Marine Biochemistry, Vietnam Academy of Science and Technology (VAST)2Graduate University of Science and Technology, VAST

References

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Published

13-07-2020

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Section

Natural Products