Phytochemical investigation and antimicrobial activity from rhizomes of alocasia odora K. Koch

Nguyen Thi Thu Ha, Nguyen Van Tuyen, Ninh The Son, Le Thi Tu Anh, Nguyen Thi Thuy Linh, Pham Minh Quan, Le Thi Hai Yen, Nguyen Van Du
Author affiliations

Authors

  • Nguyen Thi Thu Ha Institute of Chemistry, Vietnam Academy of Science and Technology,18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Nguyen Van Tuyen Institute of Chemistry, Vietnam Academy of Science and Technology,18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Ninh The Son Institute of Chemistry, Vietnam Academy of Science and Technology,18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Le Thi Tu Anh Institute of Chemistry, Vietnam Academy of Science and Technology,18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Nguyen Thi Thuy Linh Institute of Chemistry, Vietnam Academy of Science and Technology,18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Pham Minh Quan Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Le Thi Hai Yen Hanoi Medical College, 35 Doan Thi Diem, Dong Da, Ha Noi, Viet Nam
  • Nguyen Van Du Institute of Ecology and Biological Resources, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/17303

Keywords:

Alocasia odora, alkaloid, antimircobial activity

Abstract

Alocasia odora is a common plant species in Viet Nam. A phytochemical investigation of the ethyl acetate extract (EtOAc) of A. odora rhizomes collected in Tuyen Quang province led to the isolation and determination of five compounds, including three alkaloids, alocasin A (1), hyrtiosin B (2), hyrtiosulawesine (3), one mono-phenol, p-hydroxycinamic acid (4), and one fatty acid, myristic acid (5). The chemical structures of those compounds were determined by 1D and 2D-NMR spectroscopic, MS data and compared with those reported in the literature. Antimicrobial activity against microorganisms was evaluated using the broth microdilution method, showing that alkaloids 1 - 3 exhibited antimicrobial activity against reference strains with MIC values ranging from 8 µg/mL to 128 µg/mL, in which compound 1 was the most active with MIC values calculated between 8 µg/mL and 32 µg/mL. Compound 4-5 did not display antimicrobial activity at the studied concentration, MIC > 128 µg/mL. This is the first time the antimicrobial effect of A. odora has been reported.

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Published

02-08-2023

How to Cite

[1]
N. T. T. Ha, “Phytochemical investigation and antimicrobial activity from rhizomes of alocasia odora K. Koch”, Vietnam J. Sci. Technol., vol. 61, no. 5, pp. 780–786, Aug. 2023.

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Section

Natural Products

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