Assessment of some characteristics and properties of α-mangostin loaded by carrageenan/chitosan particles

Nguyen Thuy Chinh; Nguyen Thi Hien; Nguyen Thi Minh Tu; Hoang Dinh Hoa; Tran Dinh Thang; Hoang Phuong Thao; Thai Hoang

doi:10.15625/2525-2518/15967

Author affiliations

Authors

Nguyen Thuy Chinh Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, CauGiay, Ha Noi, Viet Nam https://orcid.org/0000-0001-8016-3835
Nguyen Thi Hien School of Biotechnology and Food Technology, Hanoi University of Science and Technology, 1 Dai Co Viet, Ha Noi, Viet Nam
Nguyen Thi Minh Tu School of Biotechnology and Food Technology, Hanoi University of Science and Technology, 1 Dai Co Viet, Ha Noi, Viet Nam
Hoang Dinh Hoa School of Biotechnology and Food Technology, Hanoi University of Science and Technology, 1 Dai Co Viet, Ha Noi, Viet Nam
Tran Dinh Thang Ho Chi Minh University of Technology, 475A Dien Bien Phu Street, Ward 25, Binh Thanh District, Ho Chi Minh City, Viet Nam
Hoang Phuong Thao School of Biotechnology and Food Technology, Hanoi University of Science and Technology, 1 Dai Co Viet, Ha Noi, Viet Nam
Thai Hoang Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/15967

Keywords:

α-mangostin, ionic gelation method, hydrophilic characteristic, carrageenan/chitosan blend.

Abstract

α-mangostin - an active compound extracted from mangosteen fruit peels – has been known with high anti-oxidation, antimicrobial, anti-inflammatory, antiphrastic, antiviral etc. One of disadvantages of α-mangostin is poorly soluble in aqueous solution. Loading α-mangostin by some biopolymers could improve the solubility of α-mangostin in aqueous. Therefore, this paper presents the preparation and characterization of carrageenan/chitosan particles loading α-mangostin - an active compound extracted from mangosteen fruit peels. The carrageenan/chitosan/α-mangostin particles were prepared by ionic gelation method in the presence of sodium tripolyphosphate as a cross-linking agent and potassium chloride as a gel agent. The functional groups in the particles were characterized by infrared spectroscopy. The hydrophobic/hydrophilic characteristic of the particles were assessed through the determination of contact angle of water droplet on the surface of the particles. The drug loading efficacy and solubility of carrageenan/chitosan/α-mangostin particles in buffer/ethanol solutions were also evaluated and discussed. The obtained results suggest that α-mangostin has been loaded by carrageenan/chitosan blend and the content of α-mangostin had a negligible effect on the vibrations of functional groups in the carrageenan/chitosan/α-mangostin particles. As increasing α-mangostin content in the particles, the contact angle of the particles decreased, corresponding to the increase in their hydrophilic ability. The α-mangostin loading efficacy of the particles was quite high, > 90 %. The assessment of the solubility of the particles in ethanol/buffer solutions shows that the solubility of the particles was better than that of α-mangostin.

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