Phytochemical investigation and antimicrobial activity from rhizomes of alocasia odora K. Koch
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https://doi.org/10.15625/2525-2518/17303Keywords:
Alocasia odora, alkaloid, antimircobial activityAbstract
Alocasia odora is a common plant species in Viet Nam. A phytochemical investigation of the ethyl acetate extract (EtOAc) of A. odora rhizomes collected in Tuyen Quang province led to the isolation and determination of five compounds, including three alkaloids, alocasin A (1), hyrtiosin B (2), hyrtiosulawesine (3), one mono-phenol, p-hydroxycinamic acid (4), and one fatty acid, myristic acid (5). The chemical structures of those compounds were determined by 1D and 2D-NMR spectroscopic, MS data and compared with those reported in the literature. Antimicrobial activity against microorganisms was evaluated using the broth microdilution method, showing that alkaloids 1 - 3 exhibited antimicrobial activity against reference strains with MIC values ranging from 8 µg/mL to 128 µg/mL, in which compound 1 was the most active with MIC values calculated between 8 µg/mL and 32 µg/mL. Compound 4-5 did not display antimicrobial activity at the studied concentration, MIC > 128 µg/mL. This is the first time the antimicrobial effect of A. odora has been reported.
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References
Moon J. M., Lee B. K., Chun B. J. - Toxicities of raw Alocasia odora, Hum. Exp. Toxicol. 30 (10) (2011) 1720-1723. https://doi.org/10.1177/0960327110393760. DOI: https://doi.org/10.1177/0960327110393760
Ongpoy R. C. - The medicinal properties of the Alocasia genus: A systematic review, JAASP 6 (1) (2017) 25-33. Corpus ID: 202705637.
Huang W., Yi X., Feng J., Wang Y., He X. - Piperidine alkaloids from Alocasia macrorrhiza, Phytochemistry 143 (2017) 81-86. https://doi.org/10.1016/ j.phytochem.2017.07.012. DOI: https://doi.org/10.1016/j.phytochem.2017.07.012
Prasad S. K., Bose A., Bhattacharjee A., Banerjee O., Singh S., Mukherjee S., Pal S. - Radioprotective effect of ethanolic extract of Alocasia indica on γ-irradiation- induced reproductive alterations in ovary and uterus, Int. J. Radiat. Biol. 95 (11) (2019) 1529-1542. https://doi.org/10.1080/09553002.2019.1642545. DOI: https://doi.org/10.1080/09553002.2019.1642545
Do. T. L. - Vietnamese medicinal plants and remedies, Medicine Publishing House, (2000) 122.
Le D. V., Houghton P. J., Forbes B., Corcoran O., Hylands P. J. - Wound healing activity of Alocasia odora (Roxb.) Koch, Planta Med. 72 (2006) 24-28. https://doi.org/10.1055/s-2006-949824. DOI: https://doi.org/10.1055/s-2006-949824
Thuan T. T. D., Kinh L. N. - Contributing to the study of chemical composition of Ray (Alocasia odora Roxb.) in Hue, Vietnam Medical Journal 6 (2003) 47-49.
Ha. N. T. T., Anh L. T. T., Tra N. T., Cham B. T., SonN. T. - Antimicrobacterial xanthones from Garcinia mackeaniana leaves, Vietnam J. Chem. 58 (3) (2020) 343-348. https://doi.org/10.1002/vjch.2019000183. DOI: https://doi.org/10.1002/vjch.2019000183
Zhu L., Chen C., Wang H., Ye W., and Zhou G. - Indole alkaloids from Alocasia macrorrhiza, Chem. Pharm. Bull. 60 (2012) 670-673. https://doi.org/10.1248/cpb.60.670. DOI: https://doi.org/10.1248/cpb.60.670
Kobayashi J., Murayama T., Ishibashi M., Kosuge S., Takamatsua M., Ohizumic Y., Kobayashib H., Ohtac T., Nozoec S., Sasakid T. - Hyrtiosins A and B, new indole alkaloids from the Okinawan marine sponge Hyrtios erecta, Tetrahedron 46 (1990) 7699-7702. https://doi.org/10.1016/S0040-4020(01)90065-1. DOI: https://doi.org/10.1016/S0040-4020(01)90065-1
Salmoun M., Devijver C., Daloze D., Braekman J., Soest. R.W. M. - 5-Hydroxytryptamine-derived alkaloids from two marine sponges of the genus Hyrtios, J. Nat. Prod. 65 (2002) 1173-1176. https://doi.org/10.1021/np020009. DOI: https://doi.org/10.1021/np020009+
Zhang W. M., Wang W., Zhang J. J., Wang Z. R., Wang Y., Hao W. J., Huang W. Y. - Antibacterial constituents of Hainan Morinda citrifolia (Noni) leaves. J. Food Sci. 81 (2016) 1192-1196. https://doi.org/10.1111/1750-3841.13302. DOI: https://doi.org/10.1111/1750-3841.13302
Wimalasena S., Karunawansha E. - Characterization of a new aryl alkenone and other compounds present in Horsfieldia Irya seeds, J. Natn. Sci. Coun. Sri Lanka 22 (1994) 301-304. http://doi.org/10.4038/jnsfsr.v22i3.8132 DOI: https://doi.org/10.4038/jnsfsr.v22i3.8132
Arbain D., Sinaga L. M. R., Taher M., Susanti D., Zakaria Z. A., Khotib J. - Traditional uses, phytochemistry and biological activities of Alocasia species: A systematic review, Front. Pharmacol. 13 (2022) 849704. https://doi.org/10.3389/fphar.2022.849704. DOI: https://doi.org/10.3389/fphar.2022.849704
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