Chemical constituents of dichloromethane extract from the stem bark of  Garcinia fagraeoides

Tran Thi Thu Thuy; Hoang Thi Minh Nguyet; Nguyen Phuong Thuy; Nguyen Nghia Vu; Nugyen Quoc Binh; Bui Huu````` Tai; Phan Minh Giang

doi:10.15625/2525-2518/16578

Author affiliations

Authors

Tran Thi Thu Thuy Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Hoang Thi Minh Nguyet Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology,18 Hoang Quoc Viet, Cau Giay, Hanoi, Viet Nam
Nguyen Phuong Thuy Faculty of Chemistry, VNU University of Science, Vietnam National University Hanoi, 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam
Nguyen Nghia Vu National Institute of Hygiene and Epidemiology, 1 Yersin, Hai Ba Trung, Ha Noi, Viet Nam
Nugyen Quoc Binh Vietnam National Museum of Nature, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Bui Huu````` Tai Institute of Marine Biochemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Phan Minh Giang Faculty of Chemistry, VNU University of Science, Vietnam National University Hanoi, 19 Le Thanh Tong, Hoan Kiem, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/16578

Keywords:

Garcinia fagraeoides, polyisoprenylated benzophenone, xanthone

Abstract

The Garcinia genus belonging to the Clusiaceae family (Guttiferae) has been reported to be a rich source of polyisoprenylated benzophenones, xanthones and biflavonoids with various biological activities. Garcinia fagraeoides A.Chev is an evergreen hardwood tree found only in the north provinces of Viet Nam and Guangxi province of China. Its stem bark and leaves have been used in Vietnamese traditional medicine for treatment of malaria and dermatitis diseases. In our continuing studies on chemical constituents and biological activities from the genus Garcinia, the phytochemical of Garcinia fagraeoides’s stem bark collected from Thua Thien Hue province was investigated. Repeated chromatography steps over silica gel and Sephadex LH-20 of the dichloromethane partition from the methanol extract of Garcinia fagraeoides’s stem bark led to the isolation of five compounds including one polyisoprenylated benzophenone (isogarcinol (1)), two tetraoxygenated xanthones (rubraxanthone (2), a-mangostin (3)), ferulic acid (4), and pyromeconic acid (5). Their structures were elucidated mainly by analysis of their 1D, 2D NMR spectroscopy and ESI-MS data, and by comparison with reported data. The absolute configuration of isogarcinol (1) was determined by comparison of its experimental optical rotation and NMR data with the values of its stereoisomer. This is the first reported isolation of compounds 1-5 from the stem bark of Garcinia fagraeoides.

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