PREPARATION OF ERLOTINIB HYDROCHLORIDE

Authors

  • Ta Van Dai Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology
  • Le Tat Thanh
  • Pham Quoc Long
  • Tran Thi Thu Thuy

DOI:

https://doi.org/10.15625/0866-708X/53/6/5239

Keywords:

Erlotinib, non small cell lung cancer, synthesis.

Abstract

Erlotinib hydrochloride (Tarceva) is a targeted cancer therapy drug approved for treatment of non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. An efficient and economical synthetic method of title compound from ethyl 3,4-dihydroxybenzoate is described in 6 steps with overall yield of 51 %.

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Author Biography

Ta Van Dai, Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology

Bioorganic Laboratory, Deputy Ditector

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Published

2015-12-23

Issue

Section

Articles