Neolignans from the seeds of Myristica fragrans Houtt.

Pham Van Cong; Ngo Van Hieu; Ngo Viet Duc; Pham Thuy Ha; Do Thanh Tuan; Nguyen Thi Thu Hien; Hoang Le Tuan Anh

doi:10.15625/2525-2518/16500

Author affiliations

Authors

Pham Van Cong Center for Research and Technology Transfer, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Ngo Van Hieu Center for Research and Technology Transfer, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Ngo Viet Duc Center for Research and Technology Transfer, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Pham Thuy Ha Center for Research and Technology Transfer, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Do Thanh Tuan Thaibinh University of Medicine and Pharmacy, 373 Ly Bon, Thai Binh City, Thai Binh, Viet Nam
Nguyen Thi Thu Hien Hanoi University of Mining and Geology, Pho Vien, Duc Thang, Bac Tu Liem, Ha Noi, Viet Nam
Hoang Le Tuan Anh Center for Research and Technology Transfer, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/16500

Keywords:

Myristica fragrans Houtt., neolignans

Abstract

Myristica fragrans Houtt. is an aromatic evergreen tree that belongs to the Myristicaceae family. The seeds of this plant have been widely used in culinary field as a spice and in folk medicine for treating several diseases such as stomachic, stimulant, carminative, intestinal catarrh and colic, headaches, and diarrhea, and so on. In this study, seven neolignans including one new, maceneolignan L (1), and six known neolignans: erythro-(7S,8R)-∆⁸^ʹ-4,7-dihydroxy-3,3',5'-trimethoxy-8-O-4'-neolignan (2), rhaphidecursinol B (3), maceneolignan H (4), maceneolignan F (5), (+)-(4-hydroxy-3-methoxy-1'-allyl-3',5'-dimethoxy)-8-O-4'-neolignan (6), (±) licarin A (7) were isolated from the seeds of M. fragrans Houtt. The structures of the compounds were determined by comprehensive spectroscopic analyses of their 1D-, 2D- NMR and high-resolution mass spectrometry (HR-EI-MS).

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