Chemical constituents from the leaves of Achornea rugosa (Lour.) Müll. Arg. (Euphorbiaceae)

Pham Van Huyen; Nguyen Thi Thu Hien; Nguyen Huu Huong Duyen; Nguyen Thi Dieu Thuan; Nguyen Huu Toan Phan

doi:10.15625/2525-2518/15442

Author affiliations

Authors

Pham Van Huyen Tay Nguyen Institute for Scientific Research, VAST, 116 Xo Viet Nghe Tinh, Da Lat, Viet Nam
Nguyen Thi Thu Hien Tay Nguyen Institute for Scientific Research, VAST, 116 Xo Viet Nghe Tinh, Da Lat, Viet Nam
Nguyen Huu Huong Duyen Tay Nguyen Institute for Scientific Research, VAST, 116 Xo Viet Nghe Tinh, Da Lat, Viet Nam
Nguyen Thi Dieu Thuan Tay Nguyen Institute for Scientific Research
Nguyen Huu Toan Phan Tay Nguyen Institute for Scientific Research, VAST, 116 Xo Viet Nghe Tinh, Da Lat, Viet Nam https://orcid.org/0000-0001-7390-608X

DOI:

https://doi.org/10.15625/2525-2518/15442

Keywords:

Alchornea rugosa, 3β-friedelanol, friedelan-3-one, methyl syringate, isovitexin, rhoifolin

Abstract

Alchornea is a genus of plants in the family Euphorbiaceae. It is widely distributed in tropical and subtropical regions of Africa, South Asia, Australia, and Latin America. Many species of the genus Alchornea have been used in traditional medicine in some countries around the world. Therefore, there have been many studies focusing on the chemical composition and biological activities of some species of the genus Alchornea. In the research project on the chemical composition of 4 species of Alchornea distributed in Viet Nam, we have reported compounds isolated from 3 species A. tiliaefolia, A. annamatica, and A. trewioides. Alchornea rugosa grows wild throughout Viet Nam and has been used in traditional medicine, but little is known about its chemical composition. From the leaves of species A. rugosa collected in Me Linh district, Ha Noi city, Viet Nam, five compounds including 3β-friedelanol (1), friedelan-3-one (2), methyl syringate (3), isovitexin (4), and rhoifolin (5) has been isolated from the methanol extract from its leaves by different chromatographic techniques. Their chemical structures were determined based on 1D and 2D NMR spectroscopy and mass spectrometry analysis and comparison with reference material. This is the first report on the isolation of these compounds from A. rugosa.

Downloads

Download data is not yet available.

References

Ly T. D. - 1900 useful plant species in Viet Nam, World Publisher, Ha Noi, 1993, (in Vietnamese).

Ogungbamila F. O. and Samuelsson G. - Smooth muscle relaxing flavonoids from Alchornea cordifolia, Acta Pharm. Nord. 2 (6) (1990) 421-422. PMID: 2095800.

Okoye F. B. and Osadebe O. P. - A new anti-inflammatory flavonol glycoside from Alchornea floribunda leaves, Nat. Prod. Res. 24 (3) (2010) 266-273. https://doi.org/ 10.1080/14786410902986894.

Okoye F. B., Osadebe P. O., Proksch P., Edrada-Ebel R. A., Nworu C. S., and Esimone C. O. - Anti-inflammatory and membrane-stabilizing stigmastane steroids from Alchornea floribunda leaves, Planta Med. 76 (2) (2010) 172-177. https://doi.org/10.1055/s-0029-1186032.

Cesar A. M., Oscar M. M., Jaime N. - Medicinal plants from the genus Alchornea (Euphorbiaceae): A review of their ethnopharmacology uses and phytochemistry, Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas 16 (3) (2017) 162-205.

Ho P. H. - An Illustrated Flora of Viet Nam, Volume 2, Youth publisher, Ho Chi Minh 1999, (in Vietnamese).

http://theplantlist.org/tpl1.1/record/kew-5835 (accessed 14th November 2020).

Hart N. K., Johns S. R., Lambert J. A. - Hexahydroimidazo-pyrimidines, a new class of alkaloids from Alchomea javanensis, J. Chem. Soc. D (1969) 1484-1485. https://doi.org/ 10.1039/C29690001484.

Hart N. K., Johns S. R., Lamberton H. A., and Willing R. I. - Alkaloids of Alchornea javanensis (Euphorbiaceae): The isolation of hexahydroimidazo[1,2-a]pyrimidines and guanidines, Aust. J. Chem. 23 (8) (1970) 1679-1693. https://doi.org/10.1071/CH9701679.

Kundu J. K., Rouf A. S. S., Nazmul H. M., Hasan C. M., and Rashid M. A. - Antitumor activity of epifriedelanol from Vitis trifolia, Fitoterapia 71 (2000) 577-579. https://doi.org/ 10.1016/s0367-326x(00)00191-x.

Vu K. T., Le T. K. A., Dang N. Q., Nguyen V. T., Hoang L. T. A., Nguyen X. N., Dan T. T. H., Chau V. M., Phan V. K. - Triterpenes from the leaves of Glochidion obliquum. Vietnam J. Chem. 53 (2e) (2015) 103-106. https://doi.org/10.15625/0866-7144.2015-2e-024.

Xian Y. -X., Zhou H. -L., Wang X., Yu J. -Q., Zheng Z. -J., and Yang B. -T. - Chemical constituents of Gleditsia sinensis Thorns, Asian J. Chem. 27 (3) (2015) 1063-1065. https://doi.org/10.14233/ajchem.2015.18240.

Ling T. -J., Ling W. -W., Chen Y. -J., Wan X. -C., Xia T., Du X. -F., and Zhang Z. -Z. - Antiseptic activity and phenolic constituents of the aerial parts of Vitex negundo var. cannabifolia, Molecules 15 (2010) 8469-8477. https://doi.org/10.3390/molecules 15118469.

Kiem P. V., Minh C. V., Cuong N. X., Hang D. T. T., Thao N. P., Nam N. H., Ban N. K., and Hai T. N. - Study of components flavonoids and megastigmane glucosides of Ficus callosa, Vietnam J. Chem. 49 (1) (2011) 55-59.