• Truong Thi Thu Hien
  • Ngo Thi Tuyet Mai
  • Bach Thi Tam
  • Nguyen Thi Thu Hien
  • Le Canh Viet Cuong
  • Hoang Le Tuan Anh Mientrung Institute for Scientific Research



Premna integrifolia, acteoside, premnaodoroside A, and premnaodoroside B


From the aerial parts of Premna integrifolia L., three glycosides acteoside (1), premnaodoroside A (2), and premnaodoroside B (3) were isolated. Their chemical structures were elucidated by means of ESI-MS, 1H-NMR, 13C-NMR, HSQC, HMBC spectra and in comparison with the previous literature. To our best knowledge, this is the first report of 1 and 3 from P. integrifolia.


Download data is not yet available.


Chi, V. V., 2012. Dictionary of Medicinal Plants in Vietnam. Vietnam Publisher of Medicine, 1 300-301.

Dasgupta, B., Sinha, N. K., Pandey, V. B., Ray, A. B., 1984. Major alkaloid and flavonoid of Premna integrifolia. Planta Med, 50(3), 281.

Hang, N. T. B., Ky, P. T., Van Minh, C., Cuong, N. X., Thao, N. P., Van Kiem, P., 2008. Study on the chemical constituents of Premna integrifolia L. Nat. Prod. Commun., 3(9), 1449-1452.

Purushothaman, K. K., Vasanth, S., 1986. Di-C-glycosyl flavone from Premna integrifolia. Indian Drugs, 23(8), 482.

Win, N. N., Woo, S.-Y., Ngwe, H., Prema, Wong, C. P., Ito, T., Okamoto, Y., Tanaka, M., Imagawa, H., Asakawa, Y., Abe, I., Morita, H., 2018. Tetrahydrofuran lignans: Melanogenesis inhibitors from Premna integrifolia wood collected in Myanmar. Fitoterapia, 127 308-313.

Yadav, D., Masood, N., Luqman, S., Brindha, P., Gupta, M. M., 2013. Antioxidant furofuran lignans from Premna integrifolia. Industrial Crops and Products, 41 397-402.

Nguyen, T. B. H., Pham, T. K., Chau, V. M., Nguyen, P. T., Phan, V. K., 2009. Premnaodoroside A and 10-O-trans-p-methoxycinnamoylcatalpol, two iridoid glycoside derivatives from the leaves of Premna integrifolia L. Vietnam Journal of Chemistry, 47(2), 230-235.

Yadav, D., Tiwari, N., Gupta, M. M., 2010. Diterpenoids from Premna integrifolia. Phytochemistry Letters, 3(3), 143-147.

Rahman, A., Sultana Shanta, Z., Rashid, M. A., Parvin, T., Afrin, S., Khodeza Khatun, M., Sattar, M. A., 2016. In vitro antibacterial properties of essential oil and organic extracts of Premna integrifolia Linn. Arabian Journal of Chemistry, 9 S475-S479.

Kurup, K. K., Kurup, P. A., 1964. Antibiotic substances from the root bark of Premna integrifolia. Naturwissenschaften, 51(20), 484.

Khatun, H., Majumder, R., Al, M., Alam, E. K., Jami, S. I., Alam, B., 2014. Preliminary pharmacological activity of the methanolic extract of Premna integrifolia barks in rats. Avicenna Journal of Phytomedicine, 4(3), 215-224.

Barik, B. R., Bhowmik, T., Dey, A. K., Patra, A., Chatterjee, A., Joy, S., Susan,, T., A., M.,, Kundu, A. B., 1992. Premnazole, an isoxazole alkaloid of Premna integrifolia and Gmelina arborea with anti-inflammatory activity. Fitoterapia, 63(4), 295-299.

Majumder, R., Akter, S., Naim, Z., Amin, A., Alam, B., 2014. Antioxidant and anti-diabetic activities of the methanolic extract of Premna integrifolia bark. Advances in Biological Research, 8(1), 29-36.

Gokani, R. H., Lahiri, S. K., Santani, D. D., Shah, M. B., 2011. Evaluation of anti-inflammatory and antioxidant activity of Premna integrifolia root. Journal of Complementary and Integrative Medicine, 8 1-19.

Al-Reza, S. M., Rokonuzzaman, M., Afroz, M., Hussain, M. I., Rashid, M. A., Rahman, A., 2016. Chemical composition and antioxidant activity of essential oil and organic extracts of Premna integrifolia linn. Braz. Arch. Biol. Technol., 59 1-8.

Nguyen, Q.-V., Eun, J.-B., 2011. Antioxidant activity of solvent extracts from Vietnamese medicinal plants. J. Med. Plants Res., 5(13), 2798-2811.

Alamgir, M., Rokeya, B., Hannan, J. M., Choudhuri, M. S., 2001. The effect of Premna integrifolia Linn. (Verbenaceae) on blood glucose in streptozotocin induced type 1 and type 2 diabetic rats. Pharmazie, 56(11), 903-904.

Sridharan, G., Brindha, P., JaiGanesh, C., Sivasubramanian, S., 2011. Anti tumor potential of Premna integrifolia Linn against ehrlich ascites carcinoma cell lines. Pharmacologyonline, 2 438-450.

Subramani, C., Rajakkannu, A., Rathinam, A., Gaidhani, S., Raju, I., Kartar Singh, D. V., 2017. Anti-atherosclerotic activity of root bark of Premna integrifolia Linn. in high fat diet induced atherosclerosis model rats. Journal of Pharmaceutical Analysis, 7(2), 123-128.

He, J., Hu, X.-P., Zeng, Y., Li, Y., Wu, H.-Q., Qiu, R.-Z., Ma, W.-J., Li, T., Li, C.-Y., He, Z.-D., 2011. Advanced research on acteoside for chemistry and bioactivities. Journal of Asian Natural Products Research, 13(5), 449-464.

Sudo, H., Takushi, A., Ide, T., Otsuka, H., Hirata, E., Takeda, Y., 1997. Premnethanosides A and B: Phenylethanoids from leaves of Premna subscandens. Phytochemistry, 46(6), 1147-1150.

Otsuka, H., Kubo, N., Sasaki, Y., Yamasaki, K., Takeda, Y., Seki, T., 1991. Iridoid diglycoside monoacyl esters from stems of Premna japonica. Phytochemistry, 30(6), 1917-1920.

Otsuka, H., Watanabe, E., Yuasa, K., Ogimi, C., Takushi, A., Takeda, Y., 1993. A verbascoside iridoid glucoside conjugate from Premna corymbosa var. abtusifolia. Phytochemistry, 32(4), 983-986.

Otsuka, H., Kashima, N., Hayashi, T., Kubo, N., Yamasaki, K., Padolina, W. G., 1992. Premnaodorosides A, B and C, iridoid glucoside diesters of an acyclic monoterpenediol from leaves of Premna odorata. Phytochemistry, 31(9), 3129-3133.






Natural Products