ANTI-DIABETIC EFFECTS OF GLUCOMANNO-OLIGOSACCHARIDES VIA AMPK ACTIVATION IN C2C12 MYOTUBES

Authors

  • Thien Truong Do Institute of Chemistry -Vietnamese Academy of Science and Technology
  • Nu Thi Tran Thai Binh University of Medicine and Pharmacy
  • Que Nguyet Thi Do Hanoi University of Pharmacy
  • Nhi Thi Y Tran Institute of Chemistry -Vietnamese Academy of Science and Technology

DOI:

https://doi.org/10.15625/2525-2518/59/4/15518

Keywords:

glucomanno-oligosaccharides, glucose uptake, AMP-activated protein kinase, C2C12 myotube

Abstract

Abstract-HCTN7. In this paper, antidiabetic activities of glucomanno-oligosaccharides (GMO) in vitro and in vivo were investigated. GMO significantly increased AMP-activated protein kinase (AMPK) phosphorylation in a concentration-independent manner. Treatment with 100μg/ml and 50μg/ml of GMO for 1 hour caused 1.47-fold and 1.81-fold phosphorylation of AMPK, respectively. Oral administration of GMO (6g/kg-1 of body weight day-1) lowered blood glucose levels (p < 0.05) at 120 min as compared to control group. These results suggested that GMO exhibited anti-diabetic effects via activation of AMPK and could be useful for diabetes prevention

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Author Biographies

Thien Truong Do, Institute of Chemistry -Vietnamese Academy of Science and Technology

Lab of Natural Polymer

Nu Thi Tran, Thai Binh University of Medicine and Pharmacy

Falcuty of Chemistry

Nhi Thi Y Tran, Institute of Chemistry -Vietnamese Academy of Science and Technology

Lab of Natural Polymer

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Published

2021-08-13

How to Cite

Do, T. T., Tran, N. T., Do, Q. N. T., & Tran, N. T. Y. (2021). ANTI-DIABETIC EFFECTS OF GLUCOMANNO-OLIGOSACCHARIDES VIA AMPK ACTIVATION IN C2C12 MYOTUBES. Vietnam Journal of Science and Technology, 59(4), 467. https://doi.org/10.15625/2525-2518/59/4/15518

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Section

Natural Products