Anti-diabetic effects of glucomanno-oligosaccharides via AMPK activation in C2C12 myotubes

Nu Thi Tran; Do Thi Nguyet Que; Tran Thi Y Nhi; Do Truong Thien

doi:10.15625/2525-2518/59/4/15518

Author affiliations

Authors

Nu Thi Tran Thai BinhUniversity of Medicine and Pharmacy, 373 Ly Bon Street, Thai Binh, VietNam
Do Thi Nguyet Que Hanoi University of Pharmacy, 15 Le Thanh Tong Street, Ha Noi, Viet Nam
Tran Thi Y Nhi Graduated University of Science and Technology -VAST, 18 Hoang Quoc Viet Road, Viet Nam
Do Truong Thien Graduated University of Science and Technology -VAST, 18 Hoang Quoc Viet Road, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/59/4/15518

Keywords:

glucomanno-oligosaccharides, glucose uptake, AMP-activated protein kinase, C2C12 myotube

Abstract

Abstract-HCTN7. In this paper, antidiabetic activities of glucomanno-oligosaccharides (GMO) in vitro and in vivo were investigated. GMO significantly increased AMP-activated protein kinase (AMPK) phosphorylation in a concentration-independent manner. Treatment with 100μg/ml and 50μg/ml of GMO for 1 hour caused 1.47-fold and 1.81-fold phosphorylation of AMPK, respectively. Oral administration of GMO (6g/kg^-1 of body weight day^-1) lowered blood glucose levels (p < 0.05) at 120 min as compared to control group. These results suggested that GMO exhibited anti-diabetic effects via activation of AMPK and could be useful for diabetes prevention

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