Piperine-loaded chitosan nanoparticles: preparation and characterization

Tran Thi Y Nhi, Cong Duc Trinh, Hanh Bich Pham, Tuan Le Quang, Thuy Thi Lai, Ha Thi Thanh Le, Thien Do Truong
Author affiliations

Authors

  • Tran Thi Y Nhi Institute of Chemistry -VAST, 18 Hoang Quoc Viet Road, HaNoi, Cau Giay, Viet Nam
  • Cong Duc Trinh Institute of Chemistry -VAST, 18 Hoang Quoc Viet Road, HaNoi, Cau Giay, Viet Nam
  • Hanh Bich Pham Institute of Chemistry -VAST, 18 Hoang Quoc Viet Road, HaNoi, Cau Giay, Viet Nam
  • Tuan Le Quang Institute of Chemistry -VAST, 18 Hoang Quoc Viet Road, HaNoi, Cau Giay, Viet Nam
  • Thuy Thi Lai Institute of Chemistry -VAST, 18 Hoang Quoc Viet Road, HaNoi, Cau Giay, Viet Nam
  • Ha Thi Thanh Le Institute of Chemistry -VAST, 18 Hoang Quoc Viet Road, HaNoi, Cau Giay, Viet Nam
  • Thien Do Truong Institute of Chemistry -VAST, 18 Hoang Quoc Viet Road, HaNoi, Cau Giay, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/59/4/15523

Keywords:

piperine, chitosan, nanoparticles

Abstract

  1. Abstract – HCTN7. Plasma cholesterol level plays an important role in atherosclerosis and cardiovascular diseases. Piperine, an alkaloid form of black pepper is known to reduce cholesterol uptake. In this paper, piperine-loaded chitosan nanoparticles (CTS-PIP NPs) were prepared by ionic gelation method. Molecular interactions among the components were confirmed by FT-IR spectroscopy. Transmission electron microscopy (TEM) images revealed spherical-shaped nanoparticles with diameter of <100 nm. CTS-PIP NPs displayed positive ζ-potential(ZP) of about 31.6 mV. Dynamic light scattering (DLS) particle size (PS) distribution analysis indicated the mean particle size of CTS-PIP NPs was 245.9 nm, polydispersity index of 31%

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Published

13-08-2021

How to Cite

[1]
T. T. Y. Nhi, “Piperine-loaded chitosan nanoparticles: preparation and characterization”, Vietnam J. Sci. Technol., vol. 59, no. 4, pp. 480–488, Aug. 2021.

Issue

Vol. 59 No. 4 (2021)

Section

Natural Products

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