• Tran Thi Y Nhi Institute of Chemistry -VAST
  • Cong Duc Trinh Lab of Natural Polymer
  • Thien Do Truong Lab of Natural Polymer, Institute of Chemistry, VAST
  • Tuan Le Quang Lab of Natural Polymer, Institute of Chemistry, VAST
  • Hanh Bich Pham Lab of Natural Polymer, Institute of Chemistry, VAST
  • Thuy Thi Lai Lab of Natural Polymer, Institute of Chemistry, VAST
  • Ha Thi Thanh Le Lab of Natural Polymer, Institute of Chemistry, VAST




piperine, chitosan, nanoparticles


  1. Abstract – HCTN7. Plasma cholesterol level plays an important role in atherosclerosis and cardiovascular diseases. Piperine, an alkaloid form of black pepper is known to reduce cholesterol uptake. In this paper, piperine-loaded chitosan nanoparticles (CTS-PIP NPs) were prepared by ionic gelation method. Molecular interactions among the components were confirmed by FT-IR spectroscopy. Transmission electron microscopy (TEM) images revealed spherical-shaped nanoparticles with diameter of <100 nm. CTS-PIP NPs displayed positive ζ-potential(ZP) of about 31.6 mV. Dynamic light scattering (DLS) particle size (PS) distribution analysis indicated the mean particle size of CTS-PIP NPs was 245.9 nm, polydispersity index of 31%


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Author Biography

Tran Thi Y Nhi, Institute of Chemistry -VAST

Lab of Natural Polymer


Z. Shariatinia. - Pharmaceutical applications of chitosan, Adv. Colloid Interface Sci. 263 (2019) 131–194.

J. Liu, J. Zhang, and W. Xia. - Hypocholesterolaemic effects of different chitosan samples in vitro and in vivo, Food Chem. 107 (1) (2008) 419–425.

R. Ylitalo, S. Lehtinen, E. Wuolijoki, P. Ylitalo, and T. Lehtimäki. - Cholesterol-lowering properties and safety of chitosan, Arzneimittel-Forschung/Drug Res. 52 (1), (2002) 1–7.

A. Yaghoubi, M. Ghojazadeh, S. Abolhasani, H. Alikhah, and F. Khaki-Khatibi. - Current Advances in Chitosan Nanoparticles Based Drug Delivery and Targeting, J. Cardiovasc. Thorac. Res. 7 (3) (2015) 113–117.

C. R. Quijia, V. H. Araujo, and S. Paulo. - Piperine : Chemical , biological and nanotechnological applications, 71 (2021) 1–29.

D. Anissian, Maryam Ghasemi-Kasman. - Piperine-loaded chitosan-STPP nanoparticles reduce neuronal loss and astrocytes activation in chemical kindling model of epilepsy, Int. J. Biol. Macromol. 107 (2018) 973–983.

Y. S. R. Elnaggar, S. M. Etman, D. A. Abdelmonsif, and O. Y. Abdallah. - Intranasal Piperine-Loaded Chitosan Nanoparticles as Brain-Targeted Therapy in Alzheimer’s Disease: Optimization, Biological Efficacy, and Potential Toxicity, J. Pharm. Sci. 104 (10) (2015) 3544–3556.

Nhi Tran Thi Y, Thien Do Truong, Hanh Pham Thi Bich. - Preparation and characterizaton of chitosan oligosaccharides by hydrochloric acid, 54, (6e2) (2016) 133–166.

Q. Gan, T. Wang, C. Cochrane, and P. McCarron. - Modulation of surface charge, particle size and morphological properties of chitosan-TPP nanoparticles intended for gene delivery, Colloids Surfaces B Biointerfaces. 44 (2) (2005) 65–73.

J. Panyam and V. Labhasetwar. - Biodegradable nanoparticles for drug and gene delivery to cells and tissue, Adv. Drug Deliv. Rev. 55 (3) (2003) 329–347.

B. Hu, Chengliang Pan. - Optimization of fabrication parameters to produce chitosan-tripolyphosphate nanoparticles for delivery of tea catechins, J. Agric. Food Chem. 56 (16) (2008) 7451–7458.

M. Alkholief. - Optimization of Lecithin-Chitosan nanoparticles for simultaneous encapsulation of doxorubicin and piperine, J. Drug Deliv. Sci. Technol. 52 (2019) 204–214.

S. Dutta and P. Bhattacharjee. - Nanoliposomal encapsulates of piperine-rich black pepper extract obtained by enzyme-assisted supercritical carbon dioxide extraction, J. Food Eng. 201 (2017) 49–56.




How to Cite

Nhi, T. T. Y., Trinh, C. D., Truong, T. D., Quang, T. L., Pham, H. B., Lai, T. T., & Le, H. T. T. (2021). PIPERINE-LOADED CHITOSAN NANOPARTICLES: PREPARATION AND CHARACTERIZATION. Vietnam Journal of Science and Technology, 59(4), 480. https://doi.org/10.15625/2525-2518/59/4/15523



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