INVESTIGATING THE ANTI-INFLAMMATORY ACTIVITY OF AN ETHANOLIC EXTRACT FROM ARTOCARPUS TONKINENSIS LEAVES USING A COLLAGEN ANTIBODY-INDUCED ARTHRITIC MOUSE MODEL

Authors

  • Trinh Thi Thuy Institute of Chemistry, Vietnam Academy of Science and Technology
  • Tran Duc Quan Institute of Chemistry, Vietnam Academy of Science and Technology
  • Nguyen Thanh Tam Institute of Chemistry, Vietnam Academy of Science and Technology
  • Nguyen Thi Hoang Anh Institute of Chemistry, Vietnam Academy of Science and Technology
  • Nguyen Thi Cuc Institute of Biotechnology, Vietnam Academy of Science and Technology
  • Nguyen Thi Nga Institute of Biotechnology, Vietnam Academy of Science and Technology
  • Tran Van Sung Institute of Chemistry, Vietnam Academy of Science and Technology
  • Le Thi Hong Nhung Faculty of Chemical Technology, Hanoi University of Industry
  • Nguyen Hoang Sa Department of Chemistry, Khanh Hoa University
  • Sabrina Adorisio University of Perugia
  • Domenico V. Delfino University of Perugia
  • Do Thi Thao Graduate University of Science and Technology, Vietnam Academy of Science and Technology

DOI:

https://doi.org/10.15625/2525-2518/56/3/11105

Keywords:

Artocarpus tonkinensis, autoimmune, interleukin 6, inflammation, rheumatoid arthritis, TNF-alpha

Abstract

The obtained results here demonstrate that the 70% ethanolic leaf extract of A. tonkinensis (AT2), traditionally used in Vietnamese folk medicine for treating arthritic symtoms, has beneficial effects on pro-inflammatory cytokine inhibition and in an experimental arthritic mouse model. LPS-stimulated RAW 264.7 macrophages treated with AT2 showed a significant decrease in the production of IL-6 and TNFa at concentrations of 12.5, 25 and 50 µg/mL (P<0.05), indicating its potential anti-inflammatory properties. Treatment of CAIA mice with AT2 also led to diminish the incidence of arthritis at doses of 200 and 300 mg/kg body weight.

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Author Biographies

Trinh Thi Thuy, Institute of Chemistry, Vietnam Academy of Science and Technology

Natural Products Research Laboratory

Tran Duc Quan, Institute of Chemistry, Vietnam Academy of Science and Technology

Natural Product Research Laboratory

Nguyen Thanh Tam, Institute of Chemistry, Vietnam Academy of Science and Technology

Natural Products Research Laboratory

Nguyen Thi Cuc, Institute of Biotechnology, Vietnam Academy of Science and Technology

Department of Pharmacology

Nguyen Thi Nga, Institute of Biotechnology, Vietnam Academy of Science and Technology

Department of Pharmacology

Sabrina Adorisio, University of Perugia

Department of Medicine

Domenico V. Delfino, University of Perugia

Department of Medicine

Do Thi Thao, Graduate University of Science and Technology, Vietnam Academy of Science and Technology

Department of Pharmacology

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Published

11-06-2018

Issue

Section

Natural Products