Investigating the anti-inflammatory activity of an ethanolic extract from Artocarpus tonkinensis leaves using a collagen antibody-induced arthritic mouse model

Tran Duc Quan, Dao Duc Thien, Nguyen Thanh Tam, Nguyen Thi Hoang Anh, Nguyen Thi Cuc, Nguyen Thi Nga, Tran Van Sung, Le Thi Hong Nhung, Nguyen Hoang Sa, Sabrina Adorisio, Domenico V. Delfino, Do Thi Thao, Trinh Thi Thuy
Author affiliations

Authors

  • Tran Duc Quan Institute of Chemistry,VAST, 18 Hoang Quoc Viet, CauGiay, Ha Noi, Viet Nam
  • Dao Duc Thien Institute of Chemistry,VAST, 18 Hoang Quoc Viet, CauGiay, Ha Noi, Viet Nam
  • Nguyen Thanh Tam Institute of Chemistry,VAST, 18 Hoang Quoc Viet, CauGiay, Ha Noi, Viet Nam
  • Nguyen Thi Hoang Anh Institute of Chemistry,VAST, 18 Hoang Quoc Viet, CauGiay, Ha Noi, Viet Nam
  • Nguyen Thi Cuc nstitute of Biotechnology, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Nguyen Thi Nga nstitute of Biotechnology, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Tran Van Sung Institute of Chemistry,VAST, 18 Hoang Quoc Viet, CauGiay, Ha Noi, Viet Nam
  • Le Thi Hong Nhung Hanoi University of Industry, 298 Cau Dien, Bac Tu Liem, Ha Noi, Viet Nam
  • Nguyen Hoang Sa Khanh Hoa University, 01 Nguyen Chanh, Nha Trang, Khanh Hoa, Viet Nam
  • Sabrina Adorisio University of Perugia, Piazzale Severi, S. Andrea delle Fratte, 06132 Perugia, Italy
  • Domenico V. Delfino University of Perugia, Piazzale Severi, S. Andrea delle Fratte, 06132 Perugia, Italy
  • Do Thi Thao nstitute of Biotechnology, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Trinh Thi Thuy Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/56/3/11105

Abstract

The obtained results here demonstrate that the 70% ethanolic leaf extract of A. tonkinensis (AT2), traditionally used in Vietnamese folk medicine for treating arthritic symtoms, has beneficial effects on pro-inflammatory cytokine inhibition and in an experimental arthritic mouse model. LPS-stimulated RAW 264.7 macrophages treated with AT2 showed a significant decrease in the production of IL-6 and TNFa at concentrations of 12.5, 25 and 50 µg/mL (P<0.05), indicating its potential anti-inflammatory properties. Treatment of CAIA mice with AT2 also led to diminish the incidence of arthritis at doses of 200 and 300 mg/kg body weight.

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Published

11-06-2018

How to Cite

[1]
T. D. Quan, “Investigating the anti-inflammatory activity of an ethanolic extract from Artocarpus tonkinensis leaves using a collagen antibody-induced arthritic mouse model”, Vietnam J. Sci. Technol., vol. 56, no. 3, pp. 286–294, Jun. 2018.

Issue

Vol. 56 No. 3 (2018)

Section

Natural Products

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