Studies on hepatoprotective effects of Vietnamese medicinal plants

Ngoc Khanh Pham; Katarina Bauerova; Nguyen Manh Cuong

doi:10.15625/2525-2518/17426

Author affiliations

Authors

Pham Ngoc Khanh \(^1\)Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Str., Cau Giay Dist., Hanoi 122100, Vietnam<br />\(^2\)College of Pharmacy, Peace University, 8 Bui Xuan Phai Str., Nam Tu Liem Dist., Hanoi, Vietnam https://orcid.org/0000-0003-4237-7407
Katarina Bauerova Centre of Experimental Medicine, Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Science (SAS) Dubravska cesta 9, 841 04 Bratislava, Slovakia
Nguyen Manh Cuong Natural Products SectionVietnam Journal of Science and Technology, 18 Hoang Quoc Viet Rd., Cau Giay, Hanoi, Vietnam

DOI:

https://doi.org/10.15625/2525-2518/17426

Keywords:

hepatoprotective plants, in vivo, liver failure, hepatitis

Abstract

The liver is a major organ of the human and animal body, playing an important role in metabolism, detoxification and immunomodulation. When liver tissue is damaged, liver function will decrease, leading to liver diseases such as liver fibrosis, cirrhosis, and liver cancer. Medicinal plants and natural products have provided a source of new drug candidates for the prevention and treatment of liver diseases. This review is based on scientific publications on Vietnamese plants investigated for their hepatoprotective activity during the period from 1998 to 2022. 51 medicinal plants, 38 phytoconstituents, and 8 hepatoprotective herbal formulations of Vietnamese-origin have been reported to protect the liver from the harmful effects induced by hepatotoxins, typically CCl₄ or paracetamol. Each plant's information, including its botanical name, family, part of the plant used, local name, chemical constituents, extracts or fractions used, dosage, model used, parameters obtained, histopathology, and results of hepatoprotective studies, is displayed. Also discussed is the possible mechanism of action of these hepatoprotective plants.

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