Decoration of cyclodextrin on surface of porous nano silica via disulfide bond for the controlled drug release


  • Dai Hai Nguyen Graduate University of Science and Technology, VAST,18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Thai Thanh Hoang Thi Institute of Applied Materials Science, VAST, 1 TL29, Dis. 12, Ho Chi Minh City, Viet Nam



Drug delivery system, porous nano-silica, cyclodextrin, doxorubicin


Porous nano-silica (PNS) as promising targeted drug nanocarriers has become a new area of interest in recent years due to their tunable pore sizes and large pore volumes, high chemical and thermal stability, and excellent biocompatibility. These unique structures of PNS facilitate effective protecting drugs from degradation and denaturation. However, it has certain limitations for being used in pharmaceutical such as a burst release of encapsulated drugs. In this study, the effects of grafting cyclodextrin (CD) as gatekeeper through the biodegradable disulfide bonds on doxorubicin (DOX) release was investigated. The morphology and pore channel structures of these modified PNS were assessed by transmission electron microscopy (TEM). Fourier transform infrared spectroscopy (FT-IR) was utilized to evaluate the functional groups on PNS surface. In vitro tests were conducted for the drug loading and releasing efficiency. The results demonstrated that the prepared DOX@PNS-SS-A/CD was spherical shape with an average diameter of 45 nm, drug loading efficiency of 60.52 ± 2.12%, and sustained release. More importantly, MTT assay showed that PNS-SS-A/CD was biocompatible nanocarriers. In addition, the modified PNS incorporating DOX could significantly eliminate the toxicity of free DOX. As a result, the development of PNS-SS-A/CD may offer a promising candidate for loading and sustained release of DOX in cancer therapy.


Download data is not yet available.


D. Kong; H. Pan; L. Wang; D. J. Corr; Y. Yang; S. P. Shah; J. Sheng,Effect and mechanism of colloidal silica sol on properties and microstructure of the hardened cement-based materials as compared to nano-silica powder with agglomerates in micron-scale, Cement and Concrete Composites, 98, 137-149, (2019).

A. K. Nguyen; T. H. Nguyen; B. Q. Bao; L. G. Bach; D. H. Nguyen,Efficient self-assembly of mPEG end-capped porous silica as a redox-sensitive nanocarrier for controlled doxorubicin delivery, International journal of biomaterials, 2018, (2018).

M. N. Ho; L. G. Bach; D. H. Nguyen; C. H. Nguyen; C. K. Nguyen; N. Q. Tran; N. V. Nguyen; T. T. Hoang Thi,PEGylated PAMAM dendrimers loading oxaliplatin with prolonged release and high payload without burst effect, Biopolymers, e23272, (2019).

B. Q. Bao; N. H. Le; D. H. T. Nguyen; T. V. Tran; L. P. T. Pham; L. G. Bach; H. M. Ho; T. H. Nguyen; D. H. Nguyen,Evolution and present scenario of multifunctionalized mesoporous nanosilica platform: A mini review, Materials Science and Engineering: C, 91, 912-928, (2018).

B. Zhang; H. Tan; W. Shen; G. Xu; B. Ma; X. Ji,Nano-silica and silica fume modified cement mortar used as Surface Protection Material to enhance the impermeability, Cement and Concrete Composites, 92, 7-17, (2018).

T. T. H. Thi; T. N. Q. Nguyen; D. T. Hoang; V. C. Ngo; D. H. Nguyen,Functionalized mesoporous silica nanoparticles and biomedical applications, Materials Science and Engineering: C, (2019).

U. V. Vo; C. K. Nguyen; V. C. Nguyen; T. V. Tran; B. Y. T. Thi; D. H. Nguyen,Gelatin-poly (ethylene glycol) methyl ether-functionalized porous Nanosilica for efficient doxorubicin delivery, Journal of Polymer Research, 26(1), 6, (2019).

T. T. N. Thi; T. V. Tran; N. Q. Tran; C. K. Nguyen; D. H. Nguyen,Hierarchical self-assembly of heparin-PEG end-capped porous silica as a redox sensitive nanocarrier for doxorubicin delivery, Materials Science and Engineering: C, 70, 947-954, (2017).

N. T. N. Thi; N. H. Le; U. V. Vo; C. K. Nguyen; D. H. Nguyen. Engineering of Hollow Mesoporous Silica Nanoparticles Enhancing Drug-Loading Capacity. In Proceedings of International Conference on the Development of Biomedical Engineering in Vietnam; 197-201.

D. H. T. Nguyen; D. Y. P. Nguyen; L. P. T. Pham; T. N. N. Vo; D. H. Nguyen; K. D. Park. Preparation and Characterization of Redox-Sensitive Pluronic F127-Based Nanogel as Effective Nanocarrier for Drug Delivery. In Proceedings of International Conference on the Development of Biomedical Engineering in Vietnam; pp. 189-192.

D. H. Nguyen, Design and decoration of heparin on porous nanosilica via reversible disulfide linkages for controlled drug release, The Journal of Institute of Korean Electrical and Electronics Engineers, 21(3), 320-330, (2017).

T. V. Tran; U. V. Vo; D. Y. Pham; T. H. Nguyen; N. Q. Tran; C. K. Nguyen; D. H. Nguyen,Supramolecular chemistry at interfaces: Host-guest interactions for attaching PEG and 5-fluorouracil to the surface of porous nanosilica, Green Processing and Synthesis, 5(6), 521-528, (2016).

B. Abdous; S. M. Sajjadi; L. Ma’mani,β-Cyclodextrin modified mesoporous silica nanoparticles as a nano-carrier: response surface methodology to investigate and optimize loading and release processes for curcumin delivery, Journal of Applied Biomedicine, 15(3), 210-218, (2017).

L. Dai; J. Li; B. Zhang; J. Liu; Z. Luo; K. Cai,Redox-responsive nanocarrier based on heparin end-capped mesoporous silica nanoparticles for targeted tumor therapy in vitro and in vivo, Langmuir, 30(26), 7867-7877, (2014).

T. T. Wang; J. Lan; Y. Zhang; Z. L. Wu; C. M. Li; J. Wang; C. Z. Huang,Reduced graphene oxide gated mesoporous silica nanoparticles as a versatile chemo-photothermal therapy system through pH controllable release, Journal of Materials Chemistry B, 3(30), 6377-6384, (2015).

X. Ma; C. Teh; Q. Zhang; P. Borah; C. Choong; V. Korzh; Y. Zhao,Redox-responsive mesoporous silica nanoparticles: a physiologically sensitive codelivery vehicle for siRNA and doxorubicin, Antioxidants & redox signaling, 21(5), 707-722, (2014).

P. P. Menezes; M. R. Serafini; B. V. Santana; R. S. Nunes; L. J. Quintans Jr; G. F. Silva; I. A. Medeiros; M. Marchioro; B. P. Fraga; M. R. Santos,Solid-state β-cyclodextrin complexes containing geraniol, Thermochimica Acta, 548, 45-50, (2012).




How to Cite

D. H. Nguyen and T. T. H. Thi, “Decoration of cyclodextrin on surface of porous nano silica via disulfide bond for the controlled drug release”, Vietnam J. Sci. Technol., vol. 58, no. 4, pp. 450–460, Jul. 2020.