PTP1B inhibitors from Isodon ternifolius collected in Vietnam

Minh Quan Pham; Thi Huong Thuy Le; Thi Thuy Do; Dao Cuong To; Quoc Long Pham; Nguyen Phi Hung

doi:10.15625/2525-2518/58/5/15012

Author affiliations

Authors

Minh Quan Pham Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Thi Huong Thuy Le Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Thi Thuy Do Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Dao Cuong To Faculty of Pharmacy, Phenikaa University, Yen Nghia, Ha Dong district, Ha Noi, Viet Nam
Quoc Long Pham Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Nguyen Phi Hung Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST),18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/58/5/15012

Keywords:

Isodon ternifolius, Lamiaceae, whole plant, ursane-type triterpene, sterol, PTP1B

Abstract

From the whole plant of Isodon ternifolius collected in Vietnam, four triterpens including ursaldehyde (1), ursolic acid (2), b-sitosterol (3) and b-sitosteryl ferulate (4) were purified. Their chemical structures were determined by interpretation of NMR and MS data and comparison with the literatures. Compounds 1-4 were evaluated for their inhibitory activity against PTP1B enzyme activity using in vitro assay. Compounds 1 and 2 displayed potential activities with IC₅₀ values of 16.92 ± 0.12 and 3.42 ± 0.45 μM, respectively. This is the first time that compounds 1 and 4 have been isolated from the Isodon genus and I. ternifolius has been evaluated for the PTP1B inhibitory activity.

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