Ag/Fe3O4 bifunctional nanocomposite for SERS detection of non-steroidal anti-inflammation drug diclofenac

Thi Thanh Ngan Nguyen, Duy Hai Bui, Do Chung Pham, Magdalena Osial, Marcin Pisarek, Anna Tycova, Thi Nam Pham, Thi Thanh Huong Nguyen, Thi Thu Vu
Author affiliations


  • Thi Thanh Ngan Nguyen University of Science and Technology of Hanoi
  • Duy Hai Bui University of Science and Technology of Hanoi (USTH), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
  • Do Chung Pham Hanoi National University of Education (HNUE), 136 Xuan Thuy, Cau Giay, Hanoi, Vietnam
  • Magdalena Osial Institute of Fundamental Technological Research, Polish Academy of Sciences, Pawińskiego 5B, 02-106 Warsaw, Poland
  • Marcin Pisarek Institute of Physical Chemistry, Polish Academy of Sciences, Kasprzaka 44/52, 01-224 Warsaw,Poland
  • Anna Tycova Institute of Analytical Chemistry (IAC), Czech Academy of Science (CAS), Veveří 97, 602 00 Brno, Czech Republic
  • Thi Nam Pham Institute of Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
  • Thi Thanh Huong Nguyen Institute of Tropical Technology (ITT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
  • Thi Thu Vu University of Science and Technology of Hanoi (USTH), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam



AgNPs,, Fe3O4, bifunctional, SERS, NSAIDS


In this work, a bifunctional nanocomposite based on silver and iron oxide nanoparticles (AgNPs/Fe3O4) was prepared and then used as SERS substrate (surface-enhanced Raman spectroscopy) for sensing diclofenac which is one of the most widely used non-steroid anti-inflammation drugs. AgNPs/Fe3O4 nanocomposite was synthesized by combining co-precipitation of iron oxide and in-situ reduction of silver nanoparticles. Morphology and structural studies revealed a conjugated structure in which silver nanoparticles (80 nm in diameter) were surrounded by iron oxide nanoparticles (18 nm in diameter). There is a slight blue-shift in position of plasmon peak from 405 nm for silver nanoparticles to 375 nm for AgNPs/Fe3O4 nanocomposite. Even the saturation magnetization (Ms) of the Ag/Fe3O4 nanocomposite only reached 28 emu.g-1 but still good enough for immobilizing nanocomposite structures onto the substrate. The use of AgNPs/Fe3O4 nanocomposite as SERS substrate for sensing application was demonstrated with using diclofenac as a model. The detection limit and enhancement factor of the SERS-based diclofenac sensor were found to be 10-12 M and 2.6×1010, respectively. Such kind of bifunctional nanocomposite will probably help us to avoid time-consuming process to immobilize metal nanoparticles onto the surface, and also allow us to regenerate the substrate for multiple uses.


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How to Cite

T. T. N. Nguyen, “Ag/Fe3O4 bifunctional nanocomposite for SERS detection of non-steroidal anti-inflammation drug diclofenac ”, Vietnam J. Sci. Technol., vol. 61, no. 4, Jun. 2024.




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