Evaluation of Sterculia foetida L. gum as natural based disintegrating excipient

Vu Thi Hong Quan, Nguyen Thi Quan, Mai Thanh Phong, Le Thi Kim Phung
Author affiliations

Authors

  • Vu Thi Hong Quan Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM 268 Ly Thuong Kiet Str., Ward 14, Dist. 10, Ho Chi Minh City, Viet Nam
  • Nguyen Thi Quan Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM 268 Ly Thuong Kiet Str., Ward 14, Dist. 10, Ho Chi Minh City, Viet Nam
  • Mai Thanh Phong Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM 268 Ly Thuong Kiet Str., Ward 14, Dist. 10, Ho Chi Minh City, Viet Nam
  • Le Thi Kim Phung Faculty of Chemical Engineering, Ho Chi Minh City University of Technology, VNU-HCM 268 Ly Thuong Kiet Str., Ward 14, Dist. 10, Ho Chi Minh City, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/57/3/13323

Keywords:

Sterculia foetida L. gum, controlled release excipient, HPMC E15, in vitro release testing.

Abstract

Therefore, the physicochemical properties of Sterculia foetida L. gum, including solubility, scanning electron micrographs, melting point, swelling index, pH, viscosity, loss on drying were determined. Furthermore, compressed tablets were successfully prepared for in vitro studies at many different particle sizes, concentrations of gum, rotational speeds and media in order to evaluate the effects of these parameters on the rate of drug release. Besides, SFG tablets were compared with the tablets prepared with Hydroxymethylcellulose E15. The findings indicated that Sterculia foetida L. gum exhibited an excellent potential in managed release dosage forms. 

Downloads

Download data is not yet available.

References

Sanjib B., Uttam K. S., Dipesh S., Ghanshyam S., Amit R. - Review on natural gum and mucilage and their application as excipient, Journal of Applied Pharmaceutical Research 5 (4) (2017) 13-21.

Shaikh M. D., Dhotre R.S. and Kare M. A. - Pharmacognostical and Phytochemical Evaluation of Sterculia Foetida L. Stem Bark, International Journal of Scientific Research in Science and Technology 3 (8) (2017) 1069-1072.

Chivate A. A., Poddar S. S., Abdul S. and Savant G. - Evaluation of Sterculia foetida gum as controlled release excipient, AAPS Pharm Sci Tech 9 (1) (2008) 197-204.

Namdeo T. B., Vidya R. I. and Sushilkumar S. P. - Sustained-release from Layered matrix system comprising rice bran wax and Sterculia foetida gum, International Journal of Pharmtech Research 2 (1) (2010) 989-1005.

Paresh A. P., Sushikumar S. P., Madhabhai M. P., Balkrishna K. P. - Ophthalmic minitablet with natural polymer: Sterculia foetida gum, Der Pharmacia Lettre 2 (1) (2010) 467-74.

Dixit G.R., Chavhan J.I., Kanchan P. U., Sushant M. - Formualtion and characterization of mucoadhesive buccal film of ranitidine hydrochloride using Sterculia foetida gum as polymer, Asian Journal of Pharmaceutical and Clinical Research 8 (3) (2015) 68-71.

Nayak R. K., Narayana Swammny V. B., Senthil A., Mahalaxmi R. - An In-Vitro Evaluation of Mangifera Indica Gum As A Potential Excipients for Oral Controlled Released Matrix Tablet, Pharmacologyonline 2 (2011) 360- 391.

United States Pharmacopeia 26, Apparatus for Paddle Method (Apparatus 2) (2003).

Cerf D. L., Irinei F., Muller G. - Carbohydrate Polymer 13 (4) (1990) 351–458.

Downloads

Published

01-07-2019

How to Cite

[1]
V. T. H. Quan, N. T. Quan, M. T. Phong, and L. T. K. Phung, “Evaluation of Sterculia foetida L. gum as natural based disintegrating excipient”, Vietnam J. Sci. Technol., vol. 57, no. 4, pp. 428–438, Jul. 2019.

Issue

Section

Natural Products

Most read articles by the same author(s)