Antioxidant, angiotensin converting enzyme inhibitory and anthelmintic activities of bark essential oil of Cinnamomum bejolghota (Buch.-Ham.) Sweet from North East India

Barnali Gogoi; Kashyap J. Tamuli; Snigdha Saikia; Neipihoi Lhouvum; Manobjyoti Bordoloi; Hemanta K. Sarma

doi:10.15625/2525-2518/17346

Author affiliations

Authors

Barnali Gogoi Department of Chemistry, Cotton University, Panbazar, Guwahati 781001, Assam, India
Kashyap J. Tamuli Department of Chemistry, Cotton University, Panbazar, Guwahati 781001, Assam, India
Snigdha Saikia Chemical Science and Technology Division, CSIR North East Institute of Science and Technology, Jorhat 785006, Assam, India
Neipihoi Lhouvum
Manobjyoti Bordoloi Chemical Science and Technology Division, CSIR North East Institute of Science and Technology, Jorhat 785006, Assam, India
Hemanta K. Sarma Pharmaceutical Sciences Department, Dibrugarh University, Dibrugarh 786004, Assam, India

DOI:

https://doi.org/10.15625/2525-2518/17346

Keywords:

Cinnamomum bejolghota, bark essential oil, antioxidant, angiotensin-converting enzyme inhibition, anthelmintic activity

Abstract

Cinnamomum bejolghota (Buch.-Ham.) Sweetisa traditional anthelmintic and cardiotonic medicinal plant. The essential oil extracted from the bark of C. bejolghota was characterized by gas chromatography-mass spectrometry and 28 constituents were identified. Monoterpenoids were found to be dominating chemical constituents with α-terpineol (18.57 %) as the major component of the essential oil. The antioxidant activity of the essential oil was evaluated by DPPH radical, β-carotene bleaching and reducing power assay methods. The essential oil showed in-vitro dose-response hindering activity against angiotensin-converting enzyme with an IC₅₀value of 33.43 ± 0.46 µg/mL.The essential oil also exhibited potent anthelmintic property in-vitro against Caenorhabditis elegans with an ED₅₀value of 80.53 ± 3.57 µg/mLin adult mortality assay. The inhibitory activity of essential oil against larval development assay showed an ED₅₀value of 72.40 ± 2.68 µg/mL against C. elegans larva. Further, the egg hatching assay using C. eleganseggs demonstrated an ED₅₀value of 68.27 ± 3.51 µg/mL with this essential oil. Thus, the ethnomedicinal claim has been validated for the bark essential oil, which provides an excellent scope for the development of the C. bejolghota bark essential oil as novel herbal antihypertensive and anthelmintic agents.

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