Screening for Vietnamese plant extracts with potential benefit for anti osteoclastogenesis

Le Thanh Huong; Duong Thu Trang; Nguyen Hai Dang

doi:10.15625/2525-2518/59/4/15825

Author affiliations

Authors

Le Thanh Huong University of Science and Technology of Hanoi, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam https://orcid.org/0000-0002-7628-4674
Duong Thu Trang Institute of Marine Biochemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Nguyen Hai Dang University of Science and Technology of Hanoi, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam https://orcid.org/0000-0002-4470-8321

DOI:

https://doi.org/10.15625/2525-2518/59/4/15825

Keywords:

Plant extracts, osteoclastogenesis, bone resorption, osteoporosis

Abstract

Bone's homeostasis is only achieved when there is a balance between bone formation and bone resorption. A metabolic disorder of bone-resorbing osteoclasts can lead to osteoporosis. Long-term use of anti-osteoporosis drugs can lead to undesirable side effects so traditional herbal can be a potential source of alternative medicine. In the present study, forty one Vietnamese plants (seventy methanol extracts) were screened for osteoclastogenesis inhibitory activities on RAW264.7 mouse macrophage cells. For the first time, 29 extracts from 24 species showed potential as effective inhibitors of osteoclastogenesis.

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