Synthesis and cytotoxicity of polyhydroxylated cholesterol derivatives

Dinh Thi Ha; Doan Lan Phuong; Pham Quoc Long; Ngo Dai Quang; Tran Thi Thu Thuy

doi:10.15625/2525-2518/56/4/11710

Synthesis and cytotoxicity of polyhydroxylated cholesterol derivatives

Dinh Thi Ha, Doan Lan Phuong, Pham Quoc Long, Ngo Dai Quang, Tran Thi Thu Thuy

Author affiliations

Authors

Dinh Thi Ha Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Doan Lan Phuong Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Pham Quoc Long Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Ngo Dai Quang Vietnam National Chemical Corporation, 1A Trang Tien, Hoan Kiem, Ha Noi, Viet Nam
Tran Thi Thu Thuy Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/56/4/11710

Abstract

Eight polyhydroxylated cholesterol derivatives (1-8) were prepared from cholesterol, using oxidative reagents as SeO₂, OsO₄/NMO, HCOOH/H₂O₂and BH₃/ H₂O₂. Their structures were elucidated by using physical methods including NMR 1D and 2D. These compounds were evaluated against two cancer cell lines (Hep-G2, T98). Compounds 2, 4 and 8 inhibits human hepatocellular carcinoma cell line (Hep-G2) with IC₅₀4.69, 4.98 and 2.89 µg/mL, respectively. In addition, compound 8 exhibited strong cytotoxicity against T98 cell line (glioblastoma) with IC₅₀= 2.28 μM.

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Published

06-08-2018

How to Cite

Dinh Thi Ha, Doan Lan Phuong, Pham Quoc Long, Ngo Dai Quang, & Tran Thi Thu Thuy. (2018). Synthesis and cytotoxicity of polyhydroxylated cholesterol derivatives. Vietnam Journal of Science and Technology, 56(4), 467–473. https://doi.org/10.15625/2525-2518/56/4/11710

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Issue

Vol. 56 No. 4 (2018)

Section

Natural Products

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