Chemical and pharmacological evaluation of Manglicolous lichen Graphis ajarekarii PATW. & C. R. KULK.

Polimati Haritha; Sunil Kumar Patnaik; Vinay Bharadwaj Tatipamula

doi:10.15625/2525-2518/57/3/13679

Author affiliations

Authors

Polimati Haritha Pharmaceutical Sciences Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003, Andhra Pradesh, India
Sunil Kumar Patnaik Department of Pharmaceutical Chemistry, JSS College of Pharmacy, Ootacamund- 643 001, Tamil Nadu, India
Vinay Bharadwaj Tatipamula Pharmaceutical Sciences Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam – 530 003, Andhra Pradesh, India https://orcid.org/0000-0002-9376-1911

DOI:

https://doi.org/10.15625/2525-2518/57/3/13679

Keywords:

manglicolous lichen, antioxidant, cancer, Sulforhodamine B assay

Abstract

The chemical examination of ethanolic extract of manglicolous lichen Graphis ajarekarii (Ga-Et) resulted in isolation of three known metabolites – chiodectonic acid (1), graphenone (2) and graphisquinone (3). All the isolates (1-3) and Ga-Et were screened against DPPH and superoxide free radicals, six different cancer cell lines and one normal human cell line (NHME). This work is the first report of antioxidant and cytotoxicity studies on the isolated metabolites (1-3).

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