PREPARATION OF ERLOTINIB HYDROCHLORIDE
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DOI:
https://doi.org/10.15625/0866-708X/53/6/5239Keywords:
Erlotinib, non small cell lung cancer, synthesis.Abstract
Erlotinib hydrochloride (Tarceva) is a targeted cancer therapy drug approved for treatment of non-small cell lung cancer (NSCLC), pancreatic cancer and several other types of cancer. An efficient and economical synthetic method of title compound from ethyl 3,4-dihydroxybenzoate is described in 6 steps with overall yield of 51 %.
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