Preparation and characterization of biomaterials based on polycaprolactone and chrysophanol

Nguyen Thuy Chinh; Trinh Hoang Nghia; Do Thi My; Ly Thi Ngoc Lien; Thai Hoang

doi:10.15625/2525-2518/20757

Author affiliations

Authors

Nguyen Thuy Chinh \(^1\) Institute for Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do ward, Ha Noi, 100000, Viet Nam
\(^2\) Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do ward, Ha Noi, 100000, Viet Nam https://orcid.org/0000-0001-8016-3835
Trinh Hoang Nghia \(^3\) Université du Québec à Trois-Rivières, 3351 Boulevard des Forges, Trois-Rivières, Québec, Canada
Do Thi My \(^4\) Hanoi University of Industry, 298 Cau Dien, Tay Tuu ward, Ha Noi, 100000, Viet Nam
Ly Thi Ngoc Lien \(^1\) Institute for Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do ward, Ha Noi, 100000, Viet Nam https://orcid.org/0000-0002-4315-0995
Thai Hoang \(^1\) Institute for Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do ward, Ha Noi, 100000, Viet Nam
\(^2\) Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Nghia Do ward, Ha Noi, 100000, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/20757

Keywords:

biomaterials, polycaprolactone, chrysophanol, drug release, characterization

Abstract

Polymeric biomaterials based on biodegradable, non-toxic polymers are being studied for applications in pharmaceutical and medical fields. With their advantages, many products have been developed and tested over the past decades. Chrysophanol (CSP), a natural anthraquinone isolated from fungi, rhubarb, senna, etc., exhibits good properties such as hemostasis, antibacterial ability, anti-inflammatory, anti-cancer, and improving local blood deficiency conditions, etc. Despite its numerous beneficial effects, the poor water solubility of CSP limits its absorption in the body. Polycaprolactone (PCL), a biocompatible and biodegradable polyester, has been extensively researched for polymeric biomaterials carrying drugs to achieve controlled drug release, improve water solubility, and enhance drug bioavailability. This work presents the preparation and characterization of a novel biomaterials based on the PCL and CSP at different PCL/CSP ratios prepared by the solution method. The methods, including infrared (IR) spectroscopy, scanning electron microscopy (SEM), dynamic light scattering (DLS), X-ray diffraction (XRD), differential scanning calorimetry (DSC) and ultra violet visible (UV-Vis) spectroscopy, have been used to assess the characteristics of PCL/CSP biomaterials. The obtained results indicate that CSP was loaded by PCL and they can interact to each other through physical interactions. The presence of PCL in the biomaterials contributes significantly to enhancing the solubility of CSP in aqueous environment. As a result, the CSP content released from PCL/CSP biomaterials was improved remarkably in pH 2.0 and pH 7.4 buffer solutions. Additionally, the release kinetic of CSP from the biomaterials has been calculated to find a suitable mechanism for drug release in the simulated body fluids.

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