α-Glucosidase inhibition of Vietnam's medicinal plants belonging to Zingiberaceae family and some flavonoids isolated from the rhizomes of Zingiber zerumbet Sm.
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https://doi.org/10.15625/2525-2518/18811Keywords:
Zingiber zerumbet, Zingiberaceae, flavonoids, α-glucosidaseAbstract
23 extracts from the rhizomes of seven An Giang’s medicinal plants belonging to the Zingiberaceae family were tested for α-glucosidase inhibitory activity. The screening results showed that 21/23 samples showed IC50 values less than 250 μg/mL, 17 samples with IC50 values below 100 μg/mL, and 6 samples displayed IC50 values below 10 μg/mL. Zingiber zerumbet is a perennial herb belonging to the Zingiberaceae family, and its rhizomes show various biological activities. A further phytochemical study on the CHCl3 extract of this plant furnished the isolation of seven flavonoids, consisting of naringenin (1), aromadendrin (2), kaempferol (3), iso-kaempferide (4), afzelin (5), kaempferol-3-O-(4''-O-acetyl)-α-L-rhamnopyranoside (6), and kaempferol-3-O-(2,3,4-tri-O-acetyl)-α-L-rhamnopyranoside (7). Their structures were determined based on extensive spectroscopic analysis and in comparison with previous works. Among them, compounds 1, 2, 5, and 7 have been found for the first time in this plant. All compounds possessed significant α-glucosidase inhibitory activity and showed more potent inhibitory activity than that of a positive control, acarbose (IC50, 214.5 µM or 138.2 μg/mL).
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