FLAVONOL AND LIGNAN GLYCOSIDES FROM Datura metel L.

Authors

  • Nguyen Thi Mai Hanoi University of Transport and Communications
  • Nguyen Thi Cuc Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
  • Tran Hong Quang Institute of Marine Biochemistry, Vietnam Academy of Science and Technology
  • Phan Van Kiem

DOI:

https://doi.org/10.15625/2525-2518/55/3/8811

Keywords:

Datura metel, Solanaceae, Flavonol glycoside, Lignan glycoside

Abstract

Chemical investigation of an acidic methanol extract of the whole plants of D. metel resulted in the isolation of five compounds, including kaempferol 3-O-beta-D-glucosyl(1->2)-beta-D-galactoside 7-O-beta-D-glucoside (1), kaempferol 3-O-beta-glucopyranosyl(1->2)-beta-glucopyranoside-7-O-alpha-rhamnopyranoside (2), pinoresinol O-beta-D-glucopyranoside (3), (7R,8S,7'S,8'R)-4,9,4',7'-tetrahydroxy-3,3'-dimethoxy-7,9'-epoxylignan-4-O-beta-D-glucopyranoside (4), and (7S,8R,7'S,8'S)-4,9,4',7'-tetrahydroxy-3,3'-dimethoxy-7,9'-epoxylignan-4-O-beta-D-glucopyranoside (5). Their structures were elucidated by 1D and 2D NMR and MS spectroscopic analyses as well as comparing with the data reported in the literature. The absolute configurations of compounds 4 and 5 were determined by CD spectra. It is noted that (7R,8S,7'S,8'R)-4,9,4',7'-tetrahydroxy-3,3'-dimethoxy-7,9'-epoxylignan-4-O-beta-D-glucopyranoside and (7S,8R,7'S,8'S)-4,9,4',7'-tetrahydroxy-3,3'-dimethoxy-7,9'-epoxylignan-4-O-beta-D-glucopyranoside were isolated for the first time from the Datura genus.

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Published

2017-06-16

Issue

Section

Natural Products