Secondary metabolites from Micromonospora sp. (G044)

Cao Duc Tuan; Truong Bich Ngan; Doan Thi Mai Huong; Vu Thi Quyen; Le Thi Hong Minh; Brian Murphy; Chau Van Minh; Pham Van Cuong

doi:10.15625/2525-2518/55/3/8641

Secondary metabolites from Micromonospora sp. (G044)

Cao Duc Tuan, Truong Bich Ngan, Doan Thi Mai Huong, Vu Thi Quyen, Le Thi Hong Minh, Brian Murphy, Chau Van Minh, Pham Van Cuong

Author affiliations

Authors

Cao Duc Tuan Institute of Marine Biochemistry-VAST, 18, Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Truong Bich Ngan Institute of Marine Biochemistry-VAST, 18, Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Doan Thi Mai Huong Institute of Marine Biochemistry-VAST, 18, Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Vu Thi Quyen Institute of Marine Biochemistry-VAST, 18, Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Le Thi Hong Minh Institute of Marine Biochemistry-VAST, 18, Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Brian Murphy University of Illinois at Chicago, 700 S Halsted, Chicago, Illinois, USA
Chau Van Minh Institute of Marine Biochemistry-VAST, 18, Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Pham Van Cuong Institute of Marine Biochemistry-VAST, 18, Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/55/3/8641

Keywords:

Micromonospora sp., marine microorganisms, antimicrobial activity, Cyclo-(Pro-Trp), Cyclo-(Pro-Met), Cyclo-(Pro-Val).

Abstract

In the course of our screening program, the EtOAc extract of a Micromonospora sp. (strain G044) from sponge Tethya aurantium of the sea of Côtô - Thanh Lân exhibited antimicrobial activity against Enterococcus faecalis, Bacillus cereus and Candida albicans. In this paper, we reported the isolation and structural elucidation of six secondary metabolites Cyclo-(Pro-Trp) (1), Cyclo-(Pro-Met) (2), Cyclo-(Pro-Val) (4), N-acetyltryptamine (3), uridine (5), and 2-phenylacetic acid (6) from the cultures broth of Micromonospora sp. (strain G044). The structures of 1 – 6 were determined by analyses of MS and 2D NMR data. All compounds were evaluated for their antimicrobial activity against a panel of clinically significant microorganisms. Compound 1 inhibited Escherichia coli with a MIC value of 128 µg/ml.

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Published

12-06-2017

How to Cite

[1]

C. D. Tuan, “Secondary metabolites from Micromonospora sp. (G044)”, Vietnam J. Sci. Technol., vol. 55, no. 3, pp. 251–257, Jun. 2017.

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Issue

Vol. 55 No. 3 (2017)

Section

Natural Products

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