Flavonoids and triterpenoids from Callistemon citrinus and their inhibitory effect on no production in LPS-stimulated RAW264.7 macrophages

Nguyen Manh Cuong, Pham Ngoc Khanh, Ho Viet Duc, Tran Thu Huong, Youn-Chui Kim, Pham Quoc Long, Young Ho Kim
Author affiliations

Authors

  • Nguyen Manh Cuong Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Pham Ngoc Khanh Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Ho Viet Duc Faculty of Pharmacy, Hue University of Medicine and Pharmacy, Hue University, 06 Ngo Quyen, Hue, Viet Nam
  • Tran Thu Huong Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Youn-Chui Kim College of Pharmacy, Wonkwang University, Iksan 570-749, Korea
  • Pham Quoc Long Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Young Ho Kim College of Pharmacy, Chungnam National University, Daejeon 305-764, Korea

DOI:

https://doi.org/10.15625/0866-708X/54/2/6741

Keywords:

Callistemon citrinus (Curtis) Skeels, flavonoid, triterpenoid, RAW264.7 macrophage

Abstract

Phytochemical investigation of the leaves and stems of Callistemon citrinus (Curtis) Skeels led to the isolation of 12 flavonoid and triterpenoid compounds,  including one new flavonoid, callistine A (1) and six known flavonoids 6,7- dimethyl-5,7-dihydroxy-4’-methoxy flavone (2), astragalin (3), quercetin (4), catechin (5), eucalyptin (6), and 8-demethyleucalyptin (7), along with 5 triterpenoids, 3-β-acetylmorolic acid (8), 3β-hydroxy-urs-11-en-13(28)-olide (9), betulinic acid (10), diospyrolide (11) and ursolic acid (12). Their chemical structures were determined from the spectroscopic evidences counting 1D- and 2D-NMR and HR-MS data. All the isolated compounds were examined for their anti-inflammatory activity against LPS-activated NO production in macrophage RAW264.7 cells. Among them, quercetin (4) and 3β-hydroxy-urs-11-en-13(28)-olide (9) showed potential inhibition activity in nitric oxide (NO)  production in RAW264.7 cells exposed to LPS.

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Published

12-04-2016

How to Cite

[1]
N. M. Cuong, “Flavonoids and triterpenoids from Callistemon citrinus and their inhibitory effect on no production in LPS-stimulated RAW264.7 macrophages”, Vietnam J. Sci. Technol., vol. 54, no. 2, pp. 214–223, Apr. 2016.

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