Fabrication of alpha-tocopheryl acetate-loaded nanoemulsion towards cosmetic application
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DOI:
https://doi.org/10.15625/2525-2518/17206Keywords:
alpha-tocopheryl acetate, pluronic, nanoemulsion, cosmeticAbstract
Recently, fabrication of nanoemulsion has drawn substantial interest in the field of pharmaceutical chemistry, particularly the development of nanosystems for the delivery of bioactive compounds. The idea of this material is to encapsulate and carry water-insoluble active agents to the targeted site. Our work focuses on the ideal delivery system for alpha-tocopheryl acetate (AVE), which currently covers a broad range of medications, supplementation and cosmetics. To put it in detail, we investigated different kinds of pluronic emulsifiers (pluronic F127, pluronic P123 and their mixture) to fabricate the AVE-loaded nanoemulsion particles. The structure, physicochemical properties, stability and biocompatibility of various formulations were compared using Fourier-transform infrared spectroscopy (FT-IR) spectra; Dynamic light scattering (DLS); macroscopic and microscopic images; Transmision electron microscopy (TEM) and in vitro cytotoxicity test. The obtained results exhibited a high stability of AVE-loaded pluronic mixture as compared to that of the free-AVE sample. Moreover, the dual pluronic formulation also showed a great cytocompatibility which could be utilized in topical and transdermal delivery.Downloads
References
Grebenstein N., Schumacher M., Graeve L., and Frank J. - α‐Tocopherol transfer protein is not required for the discrimination against γ‐tocopherol in vivo but protects it from side‐chain degradation in vitro, Mol. Nutr. Food. Res. 58 (5) (2014) 1052-1060. doi: 10.1002/mnfr.201300756.
Zingg J. M. - Vitamin E: regulatory role on signal transduction, IUBMB life 71 (4) (2019) 456-478. doi: 10.1002/iub.1986.
Lewis E. D., Meydani S. N., and Wu D. - Regulatory role of vitamin E in the immune system and inflammation, IUBMB life 71 (4) (2019) 487-494. doi: 10.1002/iub.1976.
Regner-Nelke L., Nelke C., Schroeter C. B., Dziewas R., Warnecke T., Ruck T., and Meuth S. G. - Enjoy carefully: the multifaceted role of vitamin E in neuro-nutrition, Int J Mol Sci. 22 (18) (2021) 10087. doi: 10.3390/ijms221810087.
Ungurianu A., Zanfirescu A., Nițulescu G., and Margină D. - Vitamin E beyond its antioxidant label, Antioxidants 10 (5) (2021) 634. doi: 10.3390/antiox10050634.
Vinardell M. P. and Mitjans M. - Nanocarriers for delivery of antioxidants on the skin, Cosmetics 2 (4) (2015) 342-354. doi: 10.3390/cosmetics2040342.
Thiele J. J., Hsieh S. N., and Ekanayake‐Mudiyanselage S. - Vitamin E: critical review of its current use in cosmetic and clinical dermatology, Dermatol Surg. 31 (2005) 805-813. doi: 10.1111/j.1524-4725.2005.31724.
Trombino S., Cassano R., Muzzalupo R., Pingitore A., Cione E., and Picci N. - Stearyl ferulate-based solid lipid nanoparticles for the encapsulation and stabilization of β-carotene and α-tocopherol, Colloids Surf B Biointerfaces 72 (2) (2009) 181-187. doi: 10.1016/j.colsurfb.2009.03.032.
de Carvalho S. M., Noronha C. M., Floriani C. L., Lino R. C., Rocha G., Bellettini I. C., Ogliari P. J., and Barreto P. L. M. - Optimization of α-tocopherol loaded solid lipid nanoparticles by central composite design, Industrial Crops and Products 49 (2013) 278-285. doi: 10.1016/j.indcrop.2013.04.054.
Doan P., Nhi T. T. Y., Nguyen D. T., Nguyen B. T., Nguyen T. P., and Tran N. Q. - Multifunctional injectable pluronic-cystamine-alginate-based hydrogel as a novel cellular delivery system towards tissue regeneration, Int. J. Biol. Macromol. 185 (2021) 592-603. doi: 10.1016/j.ijbiomac.2021.06.183.
Ganguly R., Kumar S., Tripathi A., Basu M., Verma G., Sarma H., Chaudhari D., Aswal V., and Melo J. - Structural and therapeutic properties of Pluronic® P123/F127 micellar systems and their modulation by salt and essential oil, Journal of Molecular Liquids 310 (2020) 113231. doi: 10.1016/j.molliq.2020.113231..
Basudkar V., Gharat S. A., Momin M. M., and Shringarpure M. - A review of anti-aging nanoformulations: recent developments in excipients for nanocosmeceuticals and regulatory guidelines, Critical Reviews™ in Therapeutic Drug Carrier Systems 39 (3) (2022).
Pandey A. S., Bawiskar D., and Wagh V. - Nanocosmetics and Skin Health: A Comprehensive Review of Nanomaterials in Cosmetic Formulations, Cureus 16 (1) (2024). doi: 10.7759/cureus.52754.
Neunert G., Szwengiel A., Walejko P., Witkowski S., and Polewski K. - Photostability of alpha-tocopherol ester derivatives in solutions and liposomes. Spectroscopic and LC–MS studies, Journal of Photochemistry and Photobiology B: Biology 160 (2016) 121-127. doi: 10.1016/j.jphotobiol.2016.03.032.
Nguyen D. T., Dinh V. T., Dang L. H., Nguyen D. N., Giang B. L., Nguyen C. T., Nguyen T. B. T., Thu L. V. and Tran N. Q. - Dual interactions of amphiphilic gelatin copolymer and nanocurcumin improving the delivery efficiency of the nanogels, Polymers 11 (5) (2019) 814. doi: 10.3390/polym11050814
Nguyen N. T., Bui Q. A., Nguyen H. H. N., Nguyen T. T., Ly K. L., Tran H. L. B., Doan V. N., Nhi T. T. Y., Nguyen N. H., and Nguyen N. H. - Curcuminoid co-loading platinum heparin-poloxamer P403 Nanogel increasing effectiveness in antitumor activity, Gels 8 (1) (2022) 59. doi: 10.3390/gels8010059.
Rajaei M., Rashedi H., Yazdian F., Navaei-Nigjeh M., Rahdar A. and Díez-Pascual A. M. - Chitosan/agarose/graphene oxide nanohydrogel as drug delivery system of 5-fluorouracil in breast cancer therapy, Journal of Drug Delivery Science and Technology 82 (2023) 104307. doi: 10.1016/j.jddst.2023.104307.
Li P., Dai Y. N., Zhang J. P., Wang A. Q., and Wei Q. - Chitosan-alginate nanoparticles as a novel drug delivery system for nifedipine, International journal of biomedical science: IJBS 4 (3) (2008) 221.
Upputuri R. T. P. and Mandal A. K. A. - Mathematical modeling and release kinetics of green tea polyphenols released from casein nanoparticles, Iranian Journal of Pharmaceutical Research: IJPR 18 (3) (2019) 1137.
Cheng C. C., Lee D. J., and Chen J. K. - Self-assembled supramolecular polymers with tailorable properties that enhance cell attachment and proliferation, Acta Biomaterialia 50 (2017) 476-483. doi: 10.1016/j.actbio.2016.12.031.
Anirudhan T., Varghese S., and Manjusha V. - Hyaluronic acid coated Pluronic F127/Pluronic P123 mixed micelle for targeted delivery of Paclitaxel and Curcumin, Int J Biol Macromol. 192 (2021) 950-957. doi: 10.1016/j.ijbiomac.2021.10.061.
Liu X., Li Y., He J., Zhao T., Chen C., Gu H., and Wang X. - Paclitaxel-loaded pluronic F127/P123 silica nanocapsules with surface conjugated rhTRAIL for targeted cancer therapy, RSC Advances 7 (48) (2017) 30250-30261. doi: 10.1039/c7ra04503d.
Shah F., Sarheed O., and Usman S. - Development and evaluation of a cream containing solid lipid nanoparticles loaded with Vitamin E, Pak J Pharm Sci. 34 (6) (2021).
Nguyen V. T., Nguyen T. H., Dang L. H., Vu-Quang H., and Tran N. Q. - Folate‐Conjugated Chitosan‐Pluronic P123 Nanogels: Synthesis and Characterizations towards Dual Drug Delivery, Journal of Nanomaterials 2019 (1) (2019) 1067821. doi: 10.1155/2019/1067821.
Van Thoai D., Nguyen D. T., Dang L. H., Nguyen N. H., Nguyen V. T., Doan P., Nguyen B. T., Thu L. V., Tung N. N., and Quyen T. N. - Lipophilic effect of various pluronic-grafted gelatin copolymers on the quercetin delivery efficiency in these self-assembly nanogels, J. Polym. Res. 27 (2020) 1-12. doi: 10.1007/s10965-020-02216-z.
Nguyen T. T. C., Nguyen C. K., Nguyen T. H., and Tran N. Q. - Highly lipophilic pluronics-conjugated polyamidoamine dendrimer nanocarriers as potential delivery system for hydrophobic drugs, Materials Science and Engineering: C 70 (2017) 992-999. doi:10.1016/j.msec.2016.03.073.
Wei Z., Hao J., Yuan S., Li Y., Juan W., Sha X., and Fang X. - Paclitaxel-loaded Pluronic P123/F127 mixed polymeric micelles: formulation, optimization and in vitro characterization, International Journal of Pharmaceutics 376 (1-2) (2009) 176-185. doi: 10.1016/j.ijpharm.2009.04.030.
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