Chemical constituents of marine-derived cctinomycete Streptomyces fradiae G650

Nguyen Thi Hue; Nguyen Thuy Linh; Le Thi Hong Minh; Vu Thi Thu Huyen; Doan Thi Mai Huong; Pham Van Cuong

doi:10.15625/2525-2518/17030

Author affiliations

Authors

Nguyen Thi Hue Institute of Biochemistry Marine, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Nguyen Thuy Linh Institute of Biochemistry Marine, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Le Thi Hong Minh Institute of Biochemistry Marine, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Vu Thi Thu Huyen Institute of Biochemistry Marine, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Doan Thi Mai Huong Institute of Biochemistry Marine, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
Pham Van Cuong Institute of Biochemistry Marine, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/17030

Keywords:

Streptomyces fradiae, aconitine-type diterpenoid alkaloid, cyclic dipeptide, pyrimidine, pyrimidine nucleoside

Abstract

In our continuing search for bioactive molecules, we collected a Streptomyces fradiae strain cultured from a prickly pen shell sample obtained at Van Phong, Khanh Hoa province, Vietnam. The ethyl acetate extract of Streptomyces fradiae G650 exhibited the strong inhibition against a panel of gram-positive bacteria including Enterococcus faecalis ATCC 29212, Staphylococcus aurerus ATCC 25923, Bacillus cereus ATCC 14579, and the yeast Candida albicans with the MIC values of 8, 32, 32, 8 µg/mL, respectively. As a result, from the marine-derived actinomycete Streptomyces fradiae G650, six compounds were isolated, including15α-hydroxyneoline (1), cyclo-(Leu-Tyr) (2), cyclo-(Pro-Gly) (3), 2'-deoxyuridine (4), uridine (5), and adenine (6). These compounds were structurally characterized via 1D and 2D NMR spectroscopic, mass spectrometric analyses and by comparison of the spectral data with those of previously reported data. To the best of our knowledge, 15α-hydroxyneoline (1) was reported to be isolated from microorganism for the first time.

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