Characterization of electrosprayed chitosan/PLA-PEG-PLA (copolymer) nanoparticles for encapsulation of hydrophilic drug
Author affiliations
DOI:
https://doi.org/10.15625/2525-2518/16239Keywords:
nanoparticles, electrospraying, encapsulation, chitosanAbstract
Hydrophilic drug encapsulation efficiency of nanoparticles has recently received attention from the field of medicine delivery. In this work, chitosan/PLA-PEG-PLA copolymer (CS/CP) nanoparticles containing paracetamol were produced by an electrospraying method. Interactions between functional groups of chitosan, the copolymer, and the drug in their structures were demonstrated by Fourier-transform infrared spectroscopy (FTIR) and X-ray powder diffraction (XRD). The morphology and size of the nanoparticles formed at different ratios of CS/CP were evaluated by scanning electron microscopy (SEM). As a result of the optimal conditions, the obtained CS/CP-drug nanoparticles were spherical shapes with average diameters of around 220 nm. Importantly, the nanoparticles possessed a good encapsulation efficiency of 60.25 %. These studies suggest that electrosprayed nanoparticles become compact by linkages between the active sites of the material and hydrophilic drugs, and that can significantly improve the encapsulation of therapeutic molecules.
Downloads
References
Rajesh S., James W. L. Jr. - Nanoparticle-based targeted drug delivery, NIH 86 (3) (2000) 215-223. https://doi.org/10.1016/j.yexmp.2008.12.004.
Gomes. L. P., Paschoalin.V. M. F and Del Aguila E. M.-Chitosan nanoparticles: Production, physicochemical characteristics and nutraceutical applications, Rev. Virtual Quim. 9 (1) (2017) 387-409. https://doi.org/10.21577/1984-6835.20170022.
Zhao L. M., Shi. L. E., Zhang L. Z., Chen. J. M., Shi D. D., Jang J., and Tang Z. X. -Preparation and application of chitosan nanoparticles and nanofibers, Brazilian Journal of Chemical Engineering 28 (3) (2011) 353-362.
Ahmed T. A. and Aljaeid B. M. - Preparation, characterization, and potential application of chitosan,chitosan derivatives, and chitosan metal nanoparticles in pharmaceutical drug delivery, Drug. Des. Devel. Ther. 10 (2016) 483-507.
http://dx.doi.org/10.2147/DDDT.S99651.
Saikia C., Gogoi P., and Maji T. K. - Chitosan: A promising biopolymer in drug delivery applications, J. Mol. Genet. Med. S4 (6) (2015). http://dx.doi.org/10.4172/1747-0862.S4-006.
Jelonek K., Li S., Kasperczyk J., Wu X., and Orchel A. - Effect of polymerdegradation on prolonged release of paclitaxel from filomicelles of polylactide/poly (ethylene glycol) block copolymers, Materials science and engineering C 75 (2017) 918-25. http://dx.doi.org/10.1016/j.msec.2017.03.006.
Mao H., Shan G., Bao Y., Wub Z. L., and Pan P. - Thermoresponsive physicalhydrogels of poly(lactic acid)/poly(ethylene glycol) stereoblock copolymers tuned by stereostructure and hydrophobic block sequence, Soft matter, 2016.
https://doi.org /10.1039/c6sm00517a.
Brechea Q., Chagnona G., Machadoa G., Girarda E., Nottelet B., Garricc X., and Favier D. - Mechanical behaviour's evolution of a PLA-b-PEG-b-PLA triblock copolymer during hydrolytic degradation, J. Mech. Behav Biomed 60 (2016) 288-300. http://dx.doi.org/10.1016/j.jmbbm.2016.02.015.
Danafar H., Rostamizadeh K., Davaran S., and Hamidi M. - Drugconjugated PLA–PEG–PLA copolymers: a novel approach for controlled delivery of hydrophilic drugs by micelle formation, Pharm. Dev. Technol. (2016) online 1-11.
https://doi.org /10.3109/10837450.2015.1125920.
Wu Y., Li M. and Gao H. - Polymeric micelle composed of PLA and chitosan as a drug carrier, J. Polym. Res. 16 (2009) 11-18. https://doi.org /10.1007/s10965-008-9197-z.
Cornelia V., Elena S., Raluca N. D. N, Raluca. P. D,Daniela.Pand Liliana. T.- Biocompatible materials based on plasticized poly(lactic acid), chitosan and rosemary Ethanolic Extract I. Effect of chitosan on the properties of plasticized poly(lactic acid) materials, Polymers 11 (2019) 941. https://doi.org/10.3390/polym11060941.
José A. T. H., Patricia I. T. C., Benjamín R. W., Agustín R. C., Maribel P. J., Carlos G. B. U., Norma A. R. V., and Francisco R. F. - Micro- and nanoparticles by electrospray: advances andapplications in foods, J. Agric. Food Chem. 63 (19) (2015) 4699-4707. https://doi.org/10.1021/acs.jafc.5b01403.
Morteza A., Ali A. K. Z., Mohammad A. F., and Amir A. - Evaluation of factorsaffecting size and size distribution of chitosan-electrosprayed nanoparticles, Avicenna J. Med. Biotechnol. 9 (3) (2017) 126-132.
Morteza A., Esmaeil S., Ammar E., Fariba E., Farzaneh S. L., and Amir A. - Electrosprayed chitosan nanoparticles: facile and efficient approach for bacterial transformation, International Nano Letters, Online (2017). https://doi.org/10.1007/s40089-017-0224-0.
Doan V. H. T., Sheng W. H., and Ming H. H. - Synthesis of electrosprayed chitosan
nanoparticles for drug sustained release, Nano Life 2 (1) (2012) 1-11. https://doi.org//10.1142/S1793984411000360.
Shams T., Parhizkar M., Illangakoon U. E., Orlu M., Edirisinghe M. - Core/shell microencapsulation of indomethacin/paracetamol by co-axial electrohydrodynamic atomization, Materials and Design 136 (2017) 204-213.
https://doi.org/10.1016/j.matdes.2017.09.052.
Nguyen T. T. H., Nguyen T. Q. H., Vo P. P. T., Bui X. T., Ha C. A., Huynh D. P. -Ceftiofur hydrochloride-containing chitosan micro/nano particles via electrospraying method as an efficient drug delivery system, Proceedings of the 12th AUN/SEED-net RCME & ISMSE 2019, Ho Chi Minh, 2019, pp. 163-170.
Jampafuang Y., Tongta A., and Waiprib Y. - Impact of crystalline structural differences between α- and β-chitosan on their nanoparticle formation via ionic gelation and superoxide radical scavenging activities, Polymers 11 (2019) 1-16.
https://doi.org/10.3390/polym11122010.
Hanna V., Leena P., Satu V., Milja K., Risto K., Timo L., and Jouni H. - Electrospray encapsulation of hydrophilic and hydrophobic drugs in Poly(L-lactic acid) nanoparticles, Small 5 (15), (2009), 1791–1798. https://doi.org/ 10.1002/smll.200801907.
20. Xu. Y and Milford. A. H. - Electrosprayed bovine serum albumin-loaded tripolyphosphate cross-linked chitosan capsules: Synthesis and characterization, Journal of Microencapsulation 24 (2) (2007) 143-151.
Downloads
Published
How to Cite
Issue
Section
License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
Vietnam Journal of Sciences and Technology (VJST) is an open access and peer-reviewed journal. All academic publications could be made free to read and downloaded for everyone. In addition, articles are published under term of the Creative Commons Attribution-ShareAlike 4.0 International (CC BY-SA) Licence which permits use, distribution and reproduction in any medium, provided the original work is properly cited & ShareAlike terms followed.
Copyright on any research article published in VJST is retained by the respective author(s), without restrictions. Authors grant VAST Journals System a license to publish the article and identify itself as the original publisher. Upon author(s) by giving permission to VJST either via VJST journal portal or other channel to publish their research work in VJST agrees to all the terms and conditions of https://creativecommons.org/licenses/by-sa/4.0/ License and terms & condition set by VJST.
Authors have the responsibility of to secure all necessary copyright permissions for the use of 3rd-party materials in their manuscript.
Vietnam Journal of Science and Technology (VJST) is pleased to notice: