Factors affecting fluorescent intensity of Fe3O4-cyanine 5.5 nanoparticles

Le Thi Thu Huong, Phan Ke Ke, Ung Thi Dieu Thuy, Tran Thi Lan Anh, Dong Thi Nham, Ha Phuong Thu
Author affiliations

Authors

  • Le Thi Thu Huong Instituteof Materials Science, Vietnam Academy of Science and Technology,18 Hoang Quoc Viet, Cau Giay, HaNoi, Viet Nam
  • Phan Ke Ke Instituteof Materials Science, Vietnam Academy of Science and Technology,18 Hoang Quoc Viet, Cau Giay, HaNoi, Viet Nam
  • Ung Thi Dieu Thuy Instituteof Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, HaNoi, Viet Nam
  • Tran Thi Lan Anh Instituteof Materials Science, Vietnam Academy of Science and Technology,18 Hoang Quoc Viet, Cau Giay, HaNoi, Viet Nam
  • Dong Thi Nham Instituteof Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, HaNoi, Viet Nam
  • Ha Phuong Thu Instituteof Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, HaNoi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/15968

Keywords:

fluorescent intensity, Fe3O4 nanoparticles, cyanine 5.5.

Abstract

In the diagnosis and treatment of cancer, the nano drug delivery systems have been intensively researched for many years because they are capable of concentrating drugs at the target for a longer time, while protecting other tissues in the body. Recently,, fluorescent-magnetic nanomaterials have attracted much attention from researchers in biomedicine due to these multifunctional nanomaterials have great prospects for application in multimodal biomedical imaging in combination with chemotherapy and hyperthermia. However, the factors affecting fluorescent intensity of fluorescent magnetic nanomaterials have not been investigated. In this study, we examined the dependence of fluorescent intensity on different factors in the synthesis process of Fe3O4-cyanine 5.5 nanoparticles. The results showed that Fe3O4 nanoparticles needed to be covered with a layer of NH2 group before reacting with cyanine 5.5-NHS ester. The best cyanine 5.5 NHS ester : Fe3O4 and cyanine 5.5 NHS ester : APTES ratios were 1 : 20 and 1 : 3, respectively. The drug delivery did not affect much the fluorescent property while increasing the excitation wavelength could lead to an increase in the fluorescent intensity of the system. These results are the basis to continue to evaluate the potential of Fe3O4-cyanine 5.5 nanoparticles in further in vitro and in vivo biological tests.

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Published

23-02-2022

How to Cite

[1]
L. T. T. Huong, P. K. Ke, U. T. D. Thuy, T. T. L. Anh, D. T. Nham, and H. P. Thu, “Factors affecting fluorescent intensity of Fe<sub>3</sub>O<sub>4</sub>-cyanine 5.5 nanoparticles”, Vietnam J. Sci. Technol., vol. 60, no. 1, pp. 33–42, Feb. 2022.

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Materials