PTP1B inhibitors from Isodon ternifolius collected in Vietnam

Authors

  • Minh Quan Pham Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Thi Huong Thuy Le Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Thi Thuy Do Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Dao Cuong To Faculty of Pharmacy, Phenikaa University, Yen Nghia, Ha Dong district, Ha Noi, Viet Nam
  • Quoc Long Pham Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Nguyen Phi Hung Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST),18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/58/5/15012

Keywords:

Isodon ternifolius, Lamiaceae, whole plant, ursane-type triterpene, sterol, PTP1B

Abstract

From the whole plant of Isodon ternifolius collected in Vietnam, four triterpens including ursaldehyde (1), ursolic acid (2), b-sitosterol (3) and b-sitosteryl ferulate (4) were purified. Their chemical structures were determined by interpretation of NMR and MS data and comparison with the literatures. Compounds 1-4 were evaluated for their inhibitory activity against PTP1B enzyme activity using in vitro assay. Compounds 1 and 2 displayed potential activities with IC50 values of 16.92 ± 0.12 and 3.42 ± 0.45 μM, respectively. This is the first time that compounds 1 and 4 have been isolated from the Isodon genus and I. ternifolius has been evaluated for the PTP1B inhibitory activity.

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Published

2020-10-16

How to Cite

[1]
M. Q. Pham, T. H. T. Le, T. T. Do, D. C. To, Q. L. Pham, and N. P. Hung, “PTP1B inhibitors from Isodon ternifolius collected in Vietnam”, Vietnam J. Sci. Technol., vol. 58, no. 5, pp. 533–540, Oct. 2020.

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Section

Natural Products