Investigation of antimicrobial activity and chemical constituents of Momordica charantia L. var. abbreviata Ser.

Nguyen Phuc Dam; Vo Minh Dien; Luong Huynh Vu Thanh; Phan Thi Thanh Hien; Nguyen Thi Thu Tram

doi:10.15625/2525-2518/57/2/12727

Investigation of antimicrobial activity and chemical constituents of Momordica charantia L. var. abbreviata Ser.

Nguyen Phuc Dam, Vo Minh Dien, Luong Huynh Vu Thanh, Phan Thi Thanh Hien, Nguyen Thi Thu Tram

Author affiliations

Authors

Nguyen Phuc Dam Faculty of Education, Can Tho University, Campus II, 3/2 Street, Ninh Kieu, Can Tho, Viet Nam
Vo Minh Dien Faculty of Education, Can Tho University, Campus II, 3/2 Street, Ninh Kieu, Can Tho, Viet Nam
Luong Huynh Vu Thanh Faculty of Education, Can Tho University, Campus II, 3/2 Street, Ninh Kieu, Can Tho, Viet Nam
Phan Thi Thanh Hien Faculty of Science, Mien Tay Construction University, 20B Pho Co Dieu, Vinh Long, Viet Nam
Nguyen Thi Thu Tram Faculty of Science, Can Tho University of Medicine and Pharmacy, 179 Nguyen Van Cu, Ninh Kieu, Can Tho, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/57/2/12727

Keywords:

antibacterial, antifungal, clerosterol, Cucurbitaceae, Momordica charantia

Abstract

The antimicrobial potential of the four extracts of Momordica charantia L. var. abbreviata Ser was screened against four bacterial and four fungal strains, using microbroth dilution assay. The chloroform extract showed the highest growth inhibitory activity. Phytochemical study on the bioactive chloroform extract led to the isolation of four known compounds as octadecan-1-ol (1), (23E)-5β,19-epoxycucurbita-6,23,25-trien-3β-ol (2), 5α-poriferasta-7,25-dien-3β-ol (3) and 3-O-(6′-O-palmitoyl-β-D-glucopyranosyl)-clerosterol (4). Their structures were elucidated by spectroscopic methods including 1D and 2D-NMR, MS and in comparison with literature data. Here, such metabolites were reported for the first time in M. charantia L. var. abbreviata Ser.

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Published

05-04-2019

How to Cite

[1]

N. P. Dam, V. M. Dien, L. H. V. Thanh, P. T. T. Hien, and N. T. T. Tram, “ abbreviata Ser”., Vietnam J. Sci. Technol., vol. 57, no. 2, pp. 155–161, Apr. 2019.

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Issue

Vol. 57 No. 2 (2019)

Section

Natural Products

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