Synthesis and cytotoxicity of polyhydroxylated cholesterol derivatives

Dinh Thi Ha, Doan Lan Phuong, Pham Quoc Long, Ngo Dai Quang, Tran Thi Thu Thuy
Author affiliations

Authors

  • Dinh Thi Ha Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Doan Lan Phuong Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Pham Quoc Long Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam
  • Ngo Dai Quang Vietnam National Chemical Corporation, 1A Trang Tien, Hoan Kiem, Ha Noi, Viet Nam
  • Tran Thi Thu Thuy Institute of Natural Products Chemistry, VAST, 18 Hoang Quoc Viet, Cau Giay, Ha Noi, Viet Nam

DOI:

https://doi.org/10.15625/2525-2518/56/4/11710

Abstract

Eight polyhydroxylated cholesterol derivatives (1-8) were prepared from cholesterol, using oxidative reagents as SeO2, OsO4/NMO, HCOOH/H2O2 and BH3/ H2O2. Their structures were elucidated by using physical methods including NMR 1D and 2D. These compounds were evaluated against two cancer cell lines (Hep-G2, T98). Compounds 2, 4 and 8 inhibits human hepatocellular carcinoma cell line (Hep-G2) with IC50 4.69, 4.98 and 2.89 µg/mL, respectively. In addition, compound 8 exhibited strong cytotoxicity against T98 cell line (glioblastoma) with IC50 = 2.28 μM.

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Published

06-08-2018

How to Cite

[1]
Dinh Thi Ha, Doan Lan Phuong, Pham Quoc Long, Ngo Dai Quang, and Tran Thi Thu Thuy, “Synthesis and cytotoxicity of polyhydroxylated cholesterol derivatives”, Vietnam J. Sci. Technol., vol. 56, no. 4, pp. 467–473, Aug. 2018.

Issue

Vol. 56 No. 4 (2018)

Section

Natural Products

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