Frequent occurrence of tetrodotoxin in the marine gastropod \(\textit{Nassarius glans}\) causing a food poisoning in Khanh Hoa province, Vietnam in 2020
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https://doi.org/10.15625/1859-3097/18080Keywords:
HILIC/MS-MS, Nassarius glans, poisoning, tetrodotoxin, Vietnam.Abstract
A fatal neurotoxic poisoning case happened in Khanh Hoa province in 2020 after eating a certain number of marine gastropods, later identified as Nassarius glans, one of the common marine gastropods in Vietnam. As the remaining causative food in the incident, 62 specimens were collected to examine tetrodotoxin toxicity individual variation and frequency of toxic specimens by using HILIC/MS-MS analysis. 100% of studied specimens exhibited toxicity (556 ± 821 MU/g) beyond the regulatory level of consumption (10 MU/g) for puffer(fish) recommended in Japan and extensive variation (18–4,046 MU/g). The result pointed out that only 5 g of soft tissue from N. glans (equivalent to 2–3 specimens) containing maximum toxicity detected in the present study may cause human death if consumed. Fhe first time, this study identified TTXs in the gastropods as a causative toxin in the poisoning in Vietnam. Moreover, 65.5% of studied specimens with high toxicity higher than 100 MU/g, including 16.1%, showing extremely high toxicity (> 1,000 MU/g). The results suggested that this gastropod is quite dangerous for human consumption and should be alerted to public awareness.
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Noguchi, T., Onuki, K., and Arakawa, O., 2011. Tetrodotoxin poisoning due to pufferfish and gastropods, and their intoxication mechanism. ISRN toxicology, 2011, 276939.
Ha, D. V., and Sato, S., 2010. Toxicity of some marine snails responsible for recent food poisonings in Vietnam. Vietnam Journal of Marine Science and Technology, 10(3), 89–95.
Dao, H. V., Pham, K. X., Hoang, B. X., Tanioka, M., Watanabe, R., and Suzuki, T., 2020. Occurrence of tetrodotoxin in three Nassarius gastropod species in Khanh Hoa province, Vietnam. Fisheries science, 86, 181–186.
Brillantes, S., Samosorn, W., Faknoi, S., and Oshima, Y., 2003. Toxicity of puffers landed and marketed in Thailand. Fisheries science, 69(6), 1224–1230.
Boundy, M. J., Selwood, A. I., Harwood, D. T., McNabb, P. S., and Turner, A. D., 2015. Development of a sensitive and selective liquid chromatography–mass spectrometry method for high throughput analysis of paralytic shellfish toxins using graphitised carbon solid phase extraction. Journal of Chromatography A, 1387, 1–12.
Nakamura, M., and Yasumoto, T., 1985. Tetrodotoxin derivatives in puffer fish. Toxicon, 23(2), 271–276.
Dang, Q. M., Pham, X. K., Dao, V. H., Le, H. K. H., Nguyen, T. H., Phan, B. V., and Doan, T. T., 2015. Tetrodotoxin and saxitoxin in some Nassarius species (Nassarius Duméril, 1806) collected in Khanh Hoa waters. Coll. Mar. Res. Works, 21, 70–79. (in Vietnamese with English abstract).
Hwang, D. F., Shiu, Y. C., Hwang, P. A., and Lu, Y. H., 2002. Tetrodotoxin in gastropods (snails) implicated in food poisoning in Northern Taiwan. Journal of food Protection, 65(8), 1341–1344.
Taniyama, S., Isami, Y., Matsumoto, T., Nagashima, Y., Takatani, T., and Arakawa, O., 2009. Toxicity and Toxin Profile of Tetrodotoxin Detected in the Scavenging Gastropod Nassarius (Alectrion) glans ‘Kinshibai’. Journal of the Food Hygienic Society of Japan, 50(1), 22–28.
Narita, H., Noguchi, T., Maruyama, J., Nara, M., and Hashimoto, K., 1984. Gastropod, “Hanamushirogai” Zeuxis siquijorensis. Bulletin of the Japanese Society of Scientific Fisheries, 50(1), 85–88.
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