pH-Dependence of the Optical Bio-sensor Based on DNA-carbon Nanotube

Vu Thuy Huong, Quach Kha Quang, Tran Thanh Thuy, Phan Duc Anh, Ngo Van Thanh, Nguyen Ai Viet
Author affiliations


  • Vu Thuy Huong Institute of Physics, VAST
  • Quach Kha Quang Institute of Physics, VAST
  • Tran Thanh Thuy Institute of Physics, VAST
  • Phan Duc Anh Institute of Physics, VAST
  • Ngo Van Thanh Institute of Physics, VAST
  • Nguyen Ai Viet Institute of Physics, VAST



In 2006, Daniel A. Heller et al. [1] demonstrated that carbon nanotubes (CNNTs) wrapped with DNA can be placed inside living cells and detect trace amounts of harmful contaminants using near infrared light. This discovery could lead to new types of optical sensors and biomarkers at the sub cellular level. The working principle of this optical bio-sensor from DNA and CNNTs can be explained by a simple theoretical model which was introduced in [3]. In this paper, the pH-dependence of DNA and the pH-dependence of solution around CNNTs are shown by using data analysis method. By substituting them into the same model, the pH-dependence of DNA-wrapped CNNTs was elicited in this paper. The range of parameters for workable conditions of this bio-sensor was indicated that the solution should have pH from 6 to 9 and the concentration of ions should be more than a critical value. These results are according to the experimental data and the deduction about pH and salt concentration in solution. They are very useful as using such a new bio-sensor like this in living environment.


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How to Cite

V. T. Huong, Q. K. Quang, T. T. Thuy, P. D. Anh, N. V. Thanh, and N. A. Viet, “pH-Dependence of the Optical Bio-sensor Based on DNA-carbon Nanotube”, Comm. Phys., vol. 20, no. 4, p. 309, Nov. 2012.



Published 01-11-2012

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