Hoang Kim Chi, Tran Thi Hong Ha, Le Huu Cuong, Tran Thi Nhu Hang, Nguyen Dinh Tuan, Le Thi Hong Nhung, Le Mai Huong
Author affiliations


  • Hoang Kim Chi Institute of Natural Products Chemistry, VAST, Vietnam Graduate University of Science and Technology, VAST, Vietnam
  • Tran Thi Hong Ha Institute of Natural Products Chemistry, VAST, Vietnam
  • Le Huu Cuong Institute of Natural Products Chemistry, VAST, Vietnam
  • Tran Thi Nhu Hang Institute of Natural Products Chemistry, VAST, Vietnam
  • Nguyen Dinh Tuan Institute of Natural Products Chemistry, VAST, Vietnam
  • Le Thi Hong Nhung Viet Tri University of Industry, Vinh Phuc, Vietnam
  • Le Mai Huong Institute of Natural Products Chemistry, VAST, Vietnam



Microbial isolates, marine algae, antimicrobial activity, cytotoxicity, hemolytic activity.


In the context of sources for natural products discovery are going scarcer, exploiting biotechnologically potential compounds from marine microbial symbionts is considered a relatively new trend. In our study a total of fifteen fungal strains were isolated from marine algal samples belonging to species Kappaphycus cottonii, K. striatus, Gracilaria eucheumatoides and Betaphycus gelatinus collected in Nha Trang in 2017. The in vitro biological activities, including antimicrobial, cytotoxic and hemolytic activities of ethyl acetate extracts of the fungal strains were determined. From fifteen fungal extracts, six displayed antimicrobial activity against at least one test strain. At 20 μ, four fungal extracts were found to express cytotoxic activity on two human cancer cell lines hepatocellular carcinoma (Hep-G2) and breast adenocarcinoma (MCF-7), with G. eucheumatoides being the source of the highest number of producer strains. Hemolytic activity was observed in rabbit erythrocytes under almost all fungal extracts’ effect. No apparent relationship was observed between the biological activities of fungal isolates. The biological assessments uncovered several fungal candidates, such as Bge-1.1, Kco-2.1 and Geu-1.1 with relatively potent antimicrobial and cytotoxic activities while expressing less hemolytic effect at concentrations from 20 μ to 200 μ The results evidenced the potential of exploiting natural products from associated marine microorganisms, especially those for the purpose of pharmaceutical applications.


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How to Cite

Chi, H. K., Ha, T. T. H., Cuong, L. H., Hang, T. T. N., Tuan, N. D., Nhung, L. T. H., & Huong, L. M. (2019). ANTIMICROBIAL, CYTOTOXIC AND HEMOLYTIC ACTIVITIES OF MARINE ALGAE-ASSOCIATED FUNGAL ISOLATES IN VIETNAM. Vietnam Journal of Marine Science and Technology, 18(4), 406–412.




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