Microfluidic Chip for Trapping Magnetic Nanoparticles and Heating in Terms of Biological Analysis

Tu Le Ngoc; Thinh Nguyen Cong; Lam Dai Tran; Van-Anh Nguyen; Ha Cao Hong

doi:10.15625/0868-3166/30/3/14834

Author affiliations

Authors

Tu Le Ngoc National Psychiatric Hospital No1, Thuong Tin, Hanoi, Vietnam
Thinh Nguyen Cong Department of Science, Technology and Environment, Ministry of Construction, Vietnam
Lam Dai Tran Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Vietnam and Institute for Tropical Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Hanoi, Vietnam https://orcid.org/0000-0003-1364-8001
Van-Anh Nguyen School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet, Hanoi, Vietnam
Ha Cao Hong School of Chemical Engineering, Hanoi University of Science and Technology, 1 Dai Co Viet, Hanoi, Vietnam

DOI:

https://doi.org/10.15625/0868-3166/30/3/14834

Keywords:

Microfluidic, planar-coil, magnetic nanoparticles, electromagnet, magnetic field calculation, Polydimethyl-siloxane,

Abstract

In this study, we reported the results of the design and the fabrication a planar coil in copper (square, a = 10 mm, 15mm high, 90 turns), these planar coils were integrated in a microfluidic chip for trapping magnetic nanoparticles and local heating applications. A small thermocouple (type K, 1 mm tip size) was put directly on top of the micro-channel in poly(dimethyl-siloxane) in order to measure the temperature inside the channel during applying current. The design of planar coils was based on optimizing the results of the magnetic calculation. The most suitable value of the magnetic field generated by the coil was calculated by ANSYS^® software corresponded to the different distances from the coil surface to the micro-channel bottom (magnetic field strength H_max = 825 A/m). The magnetic filed and heating relationship was balanced in order to manipulating the trapping magnetic nanoparticles and heating process. This design of the microfluidic chip can be used to develop a complex microfluidic chip using magnetic nanoparticles.

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