Impact of metal contamination to the emergence of (multi) antibiotic resistant bacteria in Thai Nguyen, Vietnam

Pham Hoang Nam, Nguyen Quang Huy, Le Thi Thu Hang, Nguyen Thy Ngoc, Nguyen Thi Kieu Oanh, Bui Van Hoi, Nguyen Ngoc Lien, Nguyen Thi Thu Hien, Le Mai Huong, Nguyen Dinh Luyen, Nguyen Thi Huyen Thu, Tran Thi Hong Minh, Nguyen Tien Dat, Marie-Genevieve Dijoux-Franca
Author affiliations

Authors

  • Pham Hoang Nam University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Nguyen Quang Huy University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Le Thi Thu Hang University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Nguyen Thy Ngoc University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Nguyen Thi Kieu Oanh University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Bui Van Hoi University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Nguyen Ngoc Lien University of Science and Technology of Hanoi, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Nguyen Thi Thu Hien Hanoi Open University, B101 Nguyen Hien Street, Ha Ba Trung District, Hanoi, Vietnam
  • Le Mai Huong Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Nguyen Dinh Luyen Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Nguyen Thi Huyen Thu Department of Pharmacy, Saint Paul Hospital, 12 Chu Van An Street, Ba Dinh District, Hanoi, Vietnam
  • Tran Thi Hong Minh Hanoi University of Natural Resources and Environment, 41A Phu Dien Road, North-Tu Liem District, Hanoi, Vietnam
  • Nguyen Tien Dat Center for Research and Technology Transfer, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Marie-Genevieve Dijoux-Franca UMR 5557, Ecologie Microbienne, CNRS, INRA, VetagroSup, UCBL, Université de Lyon, Villeurbanne, France

DOI:

https://doi.org/10.15625/1811-4989/13509

Keywords:

antibiotic, emergence, metal contamination, multidrug resistant, Pb

Abstract

Heavy metal contamination in the environment due to anthropogenic activities in industrial and agricultural areas represents stress for the living ecosystem including soil microorganisms. The adaptive response of bacterial communities to these pollutants can be observed through the increasing proportion of resistant bacteria. Our study aimed at evaluating the effect of metal contamination to the emergence of bacteria resistant to 3 common antibiotics, ie., gentamycin, sulfamethoxazole, and norfloxacin in Tan Long Pb-Zn mining site, Thai Nguyen province by a culture-dependent approach. The results showed that under moderated Pb contamination, a significant increase in prevalence of gentamycin-resistant bacteria was observed. Antibiotic susceptibility test showed 45% of isolates resistant to at least two antibiotics among gentamycin, norfloxacin, tetracyclin, imipenem, andsulfamethoxazole, and 10.4 % of isolates resistant tho three antibiotics. More detailed investigations in molecular analysis are needed to identify and genetically characterize of multi-drug resistant isolates as well as to better understand the link between metal resistance and (multi)resistance to antibiotics.

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Published

30-03-2022

How to Cite

Hoang Nam, P., Quang Huy, N., Thi Thu Hang, L., Thy Ngoc, N., Thi Kieu Oanh, N., Van Hoi, B., Ngoc Lien, N., Thi Thu Hien, N., Mai Huong, L., Dinh Luyen, N., Thi Huyen Thu, N., Thi Hong Minh, T., Tien Dat, N., & Dijoux-Franca, M.-G. (2022). Impact of metal contamination to the emergence of (multi) antibiotic resistant bacteria in Thai Nguyen, Vietnam. Vietnam Journal of Biotechnology, 20(1), 187–196. https://doi.org/10.15625/1811-4989/13509

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