Evaluation of cytotoxic activity of marine fungi isolated from sponges in Nha Trang bay

Hoai Trinh Phan Thi; Ekaterina A.  Yurchenko; Anton N.  Yurchenko; Duy Ngoc Ngo Thi; Dieu Trang Vo Thi; Thuy Hang Cao Thi; Thanh Van Tran Thi; Thinh Pham Duc; Nhu Khanh Huynh Hoang; Hung Le Dinh; Cong Dung Nguyen Ho

doi:10.15625/1859-3097/16631

Author affiliations

Authors

Phan Thi Hoai Trinh Nha Trang Institute of Technology Research and Application, VAST, Vietnam
Ekaterina A. Yurchenko G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Russia
Anton N. Yurchenko G. B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, Russia
Ngo Thi Duy Ngoc Nha Trang Institute of Technology Research and Application, VAST, Vietnam
Vo Thi Dieu Trang Nha Trang Institute of Technology Research and Application, VAST, Vietnam
Cao Thi Thuy Hang Nha Trang Institute of Technology Research and Application, VAST, Vietnam
Tran Thi Thanh Van Nha Trang Institute of Technology Research and Application, VAST, Vietnam
Pham Duc Thinh Nha Trang Institute of Technology Research and Application, VAST, Vietnam
Huynh Hoang Nhu Khanh Nha Trang Institute of Technology Research and Application, VAST, Vietnam
Le Dinh Hung Nha Trang Institute of Technology Research and Application, VAST, Vietnam
Nguyen Ho Cong Dung Pasteur Institute in Nha Trang, Khanh Hoa, Vietnam

DOI:

https://doi.org/10.15625/1859-3097/16631

Keywords:

Cytotoxic activity, marine fungi, anticancer compounds, sponges.

Abstract

Marine fungi are evaluated as a potential source for new natural compounds with bioactivities of pharmaceutical values. In this study, 66 fungal strains, isolated from 37 sponge samples in Nha Trang bay, were determined for cytotoxic activity against two human cancer cell lines, including cervical cancer (Hela) and breast cancer (MCF-7) cells using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay. The results showed that 46.9% (31/66) strains exhibited cytotoxic activity against both test cancer cell lines. Based on the internal transcribed spacer (ITS) gene sequences analysis, five isolates with significant anticancer activity were identified as Aspergillus sp. 1901NT-1.2.2, Talaromyces sp. 1901NT-1.39.3, Aspergillus subramanianii 1901NT-1.40.2, Phoma sp. 1901NT-1.45.1, and Penicillium sp. 1901NT-2.53.1. Our finding indicated that the sponge-derived fungi in Nha Trang bay might be a potential source for anticancer compounds and need further study to discover new anticancer drugs.

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