In silico study of cytochrome P450 alleles and phenotypic distribution in Vietnamese population

Authors

  • Pham Ngoc Ha LOBI Vietnam Limited Liability Company, 27/385 Luong The Vinh Road, Nam Tu Liem District, Hanoi, Vietnam
  • Nguyen Phan Tuan LOBI Vietnam Limited Liability Company, 27/385 Luong The Vinh Road, Nam Tu Liem District, Hanoi, Vietnam
  • Trinh Thi Xuan Faculty of Information Technology, Hanoi Open University, B101 Nguyen Hien Street, Hai Ba Trung District, Hanoi, VietNam
  • Truong Nam Hai Institute of Biotechnology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
  • Tran Dang Hung Faculty of Information Technology, Hanoi National University of Education, 136 Xuan Thuy Road, Cau Giay District, Hanoi, Vietnam
  • Nguyen Cuong LOBI Vietnam Limited Liability Company, 27/385 Luong The Vinh Road, Nam Tu Liem District, Hanoi, Vietnam

DOI:

https://doi.org/10.15625/1811-4989/16265

Abstract

Cytochrome P450 enzymes play an important role in phase I drug metabolism, accounting for approximately 75% of the enzymatic processes. We investigated the allele and phenotypic distributions of five important CYP genes (CYP2B6, CYP3A5, CYP2C9, CYP2C19, CYP2D6) in the Vietnamese population by using Stargazer and the PharmCAT tool to call star alleles and translating them into phenotypes based on the available dataset of PharmGKB. We compared our computational analysis of the Vietnamese distributions with those of East Asia, Europe, America and other super populations, as well as with previous experimental research. The allele frequencies and phenotypic distributions of the five important CYP genes in the Vietnamese population are similar to those in East Asia while significantly different from other populations. In silico analysis also provided consistent results with previous experimental studies. In addition, the resultant data from our research contributes to the database of genetic variations in pharmacogenetics and constructs the fundamentals for future basic and applied research. 

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Published

2022-06-30

How to Cite

Ngoc Ha, P., Phan Tuan, N., Thi Xuan, T., Nam Hai, T., Dang Hung, T., & Cuong, N. (2022). In silico study of cytochrome P450 alleles and phenotypic distribution in Vietnamese population. Vietnam Journal of Biotechnology, 20(2), 197–212. https://doi.org/10.15625/1811-4989/16265

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Articles