A study on biological activities of Bouea macrophylla Griff leaf extract

Pham Thi Hai Ha; Tran Kien Cuong; Nguyen Thi Thu Nha; Nguyen Phan Hoang Lan; Nguyen Huu Thuan Anh; Bach Long Giang; Pham Minh Quan; Tran Quoc Toan; Pham Quoc Long; Nguyen Thanh Luan

doi:10.15625/1811-4989/16059

Author affiliations

Authors

Pham Thi Hai Ha Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
Tran Kien Cuong NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh Street, Ward 13, District 4, Ho Chi Minh City, Vietnam
Nguyen Thi Thu Nha NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh Street, Ward 13, District 4, Ho Chi Minh City, Vietnam
Nguyen Phan Hoang Lan NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh Street, Ward 13, District 4, Ho Chi Minh City, Vietnam
Nguyen Huu Thuan Anh NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh Street, Ward 13, District 4, Ho Chi Minh City, Vietnam
Bach Long Giang NTT Hi-Tech Institute, Nguyen Tat Thanh University, 298-300A Nguyen Tat Thanh Street, Ward 13, District 4, Ho Chi Minh City, Vietnam
Pham Minh Quan Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
Tran Quoc Toan Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
Pham Quoc Long Graduate University of Science and Technology, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet Road, Cau Giay District, Hanoi, Vietnam
Nguyen Thanh Luan Department of Science and Technology and International Affairs, HUTECH University, 475A Dien Bien Phu Street, Ward 25, Binh Thanh District, Ho Chi Minh City, Vietnam

DOI:

https://doi.org/10.15625/1811-4989/16059

Keywords:

antibacterial, anticancer, antioxidant, bioactive compounds, Bouea macrophylla.

Abstract

Bouea macrophylla in the family Anacardiaceae is a prominent fruit in Southeast Asia, especially in Vietnam with several prospects. This study focused on the bioactive components and biological effects of B. macrophylla ethanol leaf extract. Phytochemical analysis revealed various compounds including polyphenol, tannin, saponin, reducing agent, flavonoid, and essential oil in the extract. The DPPH assay showed the remarkable antioxidant capacity of the extract (IC₅₀ = 6.4 ± 0.08 μg/ml), which is stronger than ascorbic acid (IC₅₀= 9.35 ± 0.12 μg/ml). The disc diffusion method and minimal inhibitory concentration test displayed the significant antibacterial ability of the extract against Listeria monocytogenes, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhimurium, and Bacillus cereus at the range from 10 - 15 mg/ml, but no activity against Staphylococcus aureus. Moreover, the MTT assay was performed the noticeable anticancer activity of the extract in HepG2 (IC₅₀= 72.33 ± 0.68 μg/ml), and MCF-7 cells (IC₅₀= 50.25 ± 1.36 μg/ml). Taken together, this study indicated the effects of B. macrophylla ethanol leaf extract from Vinh Long Province, Vietnam on antibacterial, antioxidant, and anticancer properties. Therefore, B. macrophylla possibly is used in the food industry and medicine.

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References

Arapoc, D.J., Mohamed Zaffar Ali Mohamed Amiroudine, Zainah Adam, Rosniza Razali, & Shafii Khamis, 2016. Antiproliferative Activities of Bouea macrophylla Seed Extracts. R&D Seminar 2016: Research and Development Seminar 2016, Malaysia

Kochummen, K. M., 1996. “Anacardiaceae.” In: Tree Flora of Sabah and Sarawak, Vol. 2, edited by Soepadmo, E. et al. Kepong: FRIM, Sabah Forestry Department, Sandakan and Sarawak Forestry Department

Laila Fitri, Irham Taufiqurrahman, Irnamanda DH., 2018. Phytochemical and cytotoxicity testing of ramania leaves (Bouea macrophylla Griffith) ethanol extract toward Vero cells using mtt assay method. Jur. Ked. Gigi, Vol III. No 1. Maret:51-56.

Lutfi Chabib, Wildan Khairi Muhtadi, Muhammad Ikhwan Rizki, and Rifazul Aulia Rahman, Mohamad Rahman Suhendri, and Arif Hidayat., 2018. Potential medicinal plants for improve the immune system from Borneo Island and the prospect to be developed as nanomedicine. MATEC Web of Conferences 154, 04006.

Ngoc Hong Nguyen, Thuy Trang Nguyen, Phu Cuong Ma, Qui Thanh Hoai Ta, Thuc-Huy Duong and Van Giau Vo., 2020. Potential Antimicrobial and Anticancer Activities of an Ethanol Extract from Bouea macrophylla. Molecules, 25, 1996; doi:10.3390/molecules25081996.

Nuning Rahmawati, Fanie Indrian Mustofa, Sari Haryanti., 2020. Diversity of medicinal plants utilized by To Manui ethnic of Central Sulawesi, Indonesia. Biodiversitas. Volume 21, Number 1,s375-392. doi: 10.13057/biodiv/d210145.

Sasitorn Chusri, Naruephan Sinvaraphan, Ploypailin Chaipak, Atita Luxsananuwong, and Supayang Piyawan Voravuthikunchai., 2014. Evaluation of Antibacterial Activity, Phytochemical Constituents, and Cytotoxicity Effects of Thai Household Ancient Remedies. The Journal of Alternative And Complementary Medicine. Volume 20, Number 12, 909-918.

Siwaphon Paksee, Jiraporn Kantapan, Pornthip Chawapun, Padchanee Sangthong, Nathupakorn Dechsupa., 2019. Maprang seed extracts suppressed chemoresistant propertes of breast cancer cells survived from ionizing radiaton treatment via the regulaton of ABCB1 genes. Journal of Associated Medical Sciences; 52(3):185-192

Tô Nguyễn Phước Mai, Nguyễn Hải Âu, Lê Ngọc Dương và Trần Thanh Trúc., 2017. Sự thay đổi tính chất hóa lý của quả thanh trà theo độ tuổi thu hoạch. Tạp chí Khoa học Trường Đại học Cần Thơ. 49b: 27-34.

Wipob Suttana, Nathupakorn Dechsupa, Samlee Mankhetkorn., 2013. Preparation of Maprang Seed Extracts and Evaluation Their Anti-Proliferative Activity against Drug-Sensitive and Drug -Resistant Leukemic and Lung Cancer Cells. Srinagarind Med J.; 28(1): 100-9.

Zainah Adam, Hazlina Ahmad Hassali, Rosniza Razali., 2016.

Phytochemicals Content, Antioxidant and α-Glucosidase Inhibition Activity of Bouea macrophylla Griff Seed Extract. R&D Seminar, 2016: Research and Development Seminar 2016, Malaysia

Zainah Adam, Mohamed Zaffar Ali Mohamed Amiroudine, Daryl Jesus Arapoc, & Shafii Khamis., 2015. Utilization of Cell Reporter System and Enspire Multimode Plate Reader in Anti-Cancer Research. NTC 2015: Nuclear Technical Convention 2015, Malaysia.