Genetic variation of mitochondrial sequence-hv2 in Vietnamese populations

Authors

  • Do Manh Hung
  • Nguyen Hai Ha
  • Pham Nhat Khoi
  • Vu Phuong Nhung
  • Nguyen Van Phong
  • Nguyen Thuy Duong
  • Nong Van Hai
  • Nguyen Dang Ton

DOI:

https://doi.org/10.15625/0866-7160/v38n2.7071

Keywords:

D-loop, HV2, haplogroup, languague system, mitochondrial DNA.

Abstract

HV1 and HV2, which located in control D-loop region of mitochondrial, are the hyper-variable parts of mitochondrial DNA (mtDNA). Therefore, these two sequences were often used for evolutional and forensic science. In order to determine the genetic variation of populations belong to Nam-A and Nam-Dao language systems, we sequenced and analyzed the mtDNA HV2 region of individuals from four ethic groups: Kinh, Muong, Ede and Jarai which represent for those language systems. Study subjects are peripheral blood of 169 individuals belonging to four populations: Kinh, Muong, Ede and Jarai. HV2 regions were sequenced by Sanger sequencing. As a result, the analyzed mitochondrial control region sequences could be assigned to 79 different haplogroups, with the dominant proportion of three haplogroups: R, B and F. Donors representing Kinh or Muong population revealed higher haplogroup composition variation in comparison with those affiliated with Jarai or Ede. In addition, it was indicated that the 4 populations shared the genetic analogy with other populations inhabited in Southeast Asia and South Asia.

 

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Published

25-04-2016

How to Cite

Hung, D. M., Ha, N. H., Khoi, P. N., Nhung, V. P., Phong, N. V., Duong, N. T., Hai, N. V., & Ton, N. D. (2016). Genetic variation of mitochondrial sequence-hv2 in Vietnamese populations. Academia Journal of Biology, 38(2), 243–249. https://doi.org/10.15625/0866-7160/v38n2.7071

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